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The toxicity of cadmium (Cd) chloride was studied in ovariectomized (OX) female rats and non-OX female rats after intravenous administration of the compound at doses of 2.0 and 3.0 mg/kg for 14 days. Mild hypochromic microcytic anemia developed in all rats treated with Cd, but growth retardation in the OX rats was more prominent than that in the non-OX rats. There was an increase of AST and ALT and a decrease of total cholesterol and the A/G ratio in both OX and non-OX rats treated with Cd. The hepatic and renal Cd concentrations increased in a dose-dependent manner, and the concentrations in both organs on Day 14 were comparable in the 3.0 mg/kg OX group (liver, 270.0 +/- 39.6 micrograms/g; kidney, 121.3 +/- 10.1 micrograms/g) and non-OX group (liver, 277.0 +/- 29.9 micrograms/g; kidney, 100.8 +/- 1.3 micrograms/g). Hepatocyte necrosis developed only in OX rats treated with Cd, and the nephrotoxicity of Cd was also notably enhanced by ovariectomy, since Cd nephropathy affected the proximal convoluted epithelium more severely and more frequently in OX rats than in non-OX rats. BrdU-labeled cells in the renal cortex were increased by approximately 2.7-fold in OX rat (7.4 cells/mm2) over those in the renal cortex in non-OX rat (2.7 cells/mm2). In conclusion, the present study demonstrated that ovariectomy enhanced Cd-induced nephrotoxicity and hepatotoxicity in rats.
O Katsuta, and
H Hiratsuka, and
J Matsumoto, and
M Tsuchitani, and
T Umemura, and
F Marumo
January 1997,
Drug metabolism reviews,
O Katsuta, and
H Hiratsuka, and
J Matsumoto, and
M Tsuchitani, and
T Umemura, and
F Marumo
February 1997,
Indian journal of experimental biology,
O Katsuta, and
H Hiratsuka, and
J Matsumoto, and
M Tsuchitani, and
T Umemura, and
F Marumo
August 2011,
Saudi medical journal,
O Katsuta, and
H Hiratsuka, and
J Matsumoto, and
M Tsuchitani, and
T Umemura, and
F Marumo
June 2021,
Archives of physiology and biochemistry,
O Katsuta, and
H Hiratsuka, and
J Matsumoto, and
M Tsuchitani, and
T Umemura, and
F Marumo
December 1982,
Chemico-biological interactions,
O Katsuta, and
H Hiratsuka, and
J Matsumoto, and
M Tsuchitani, and
T Umemura, and
F Marumo
July 1984,
Toxicology and applied pharmacology,
O Katsuta, and
H Hiratsuka, and
J Matsumoto, and
M Tsuchitani, and
T Umemura, and
F Marumo
March 1996,
The Journal of pharmacology and experimental therapeutics,
O Katsuta, and
H Hiratsuka, and
J Matsumoto, and
M Tsuchitani, and
T Umemura, and
F Marumo
October 2020,
Naunyn-Schmiedeberg's archives of pharmacology,
O Katsuta, and
H Hiratsuka, and
J Matsumoto, and
M Tsuchitani, and
T Umemura, and
F Marumo
February 2023,
Heliyon,
O Katsuta, and
H Hiratsuka, and
J Matsumoto, and
M Tsuchitani, and
T Umemura, and
F Marumo
January 1984,
Annals of clinical and laboratory science,
