-transparent.png){kind=logo}
A biopsy taken from the right m. gastrocnemius of a sporadic case of central core disease has been investigated by electronmicroscopy. Both longitudinal and cross sections show cores, which are partially in the centre and partially near the sarcolemma of the muscle fibres. These cores are more or less sharply delimited from the intact areas of the muscle fibres. A zone showing a severe destruction of the regularly fibrillar structure is observed in the centre of each core. This destruction zone is surrounded by a transition zone, in which a partial lesion of the fibrillar structure is found whereas the sarcomeric segmentation is preserved. The width of the interfibrillar sarcoplasm is reduced, frequently, however, mitochondria containing cristae of normal structure are observed. The cores are foundlimited by target fibres. Pathogenetically, the damages of z-lines are assumed to be dominant in the formation of the cores.
W Meerbach, and
A Lageman, and
W Dietz
January 1977,
Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie,
W Meerbach, and
A Lageman, and
W Dietz
January 1974,
Anales espanoles de pediatria,
W Meerbach, and
A Lageman, and
W Dietz
April 1980,
Rinsho shinkeigaku = Clinical neurology,
W Meerbach, and
A Lageman, and
W Dietz
February 1978,
Zeitschrift fur Orthopadie und ihre Grenzgebiete,
W Meerbach, and
A Lageman, and
W Dietz
June 1976,
Zeitschrift fur Orthopadie und ihre Grenzgebiete,
W Meerbach, and
A Lageman, and
W Dietz
May 1975,
Klinische Monatsblatter fur Augenheilkunde,
W Meerbach, and
A Lageman, and
W Dietz
August 1977,
Nihon Jibiinkoka Gakkai kaiho,
W Meerbach, and
A Lageman, and
W Dietz
February 1976,
Klinische Wochenschrift,
W Meerbach, and
A Lageman, and
W Dietz
January 1974,
Verhandlungen der Deutschen Gesellschaft fur Pathologie,
W Meerbach, and
A Lageman, and
W Dietz
December 1975,
Nippon Ganka Gakkai zasshi,
