Biomaterial Database

Application of the zinc protoporphyrin (ZP) test as a monitor of occupational exposure to lead. 1977

M M Joselow, and J Flores

Zinc protoporphyrin, the predominant abnormal metabolite that appears in whole blood as a result of chronic lead absorption, can be assayed fluorometrically in diluted whole blood with great sensitivity. An extremely simple and rapid test for the effects of lead absorption is described that is based on this assay. Results of a field trial show a characteristic dose-response relationship between zinc protoporphyrin and lead, and indicate that this test should be seriously considered as a monitor for the effects of chronic lead adsorption.

UI	MeSH Term	Description	Entries
D007854	Lead	A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D007855	Lead Poisoning	Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.	Poisoning, Lead,Lead Poisonings,Poisonings, Lead
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009787	Occupational Medicine	Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings.	Industrial Medicine,Medicine, Industrial,Medicine, Occupational
D011166	Porphyrins	A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.	Porphyrin
D011524	Protoporphyrins	Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.
D004781	Environmental Exposure	The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.	Exposure, Environmental,Environmental Exposures,Exposures, Environmental
D005470	Fluorometry	An analytical method for detecting and measuring FLUORESCENCE in compounds or targets such as cells, proteins, or nucleotides, or targets previously labeled with FLUORESCENCE AGENTS.	Fluorimetry,Fluorometric Analysis,Analysis, Fluorometric
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man