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A single standardized drop of 1.0% prednisolone acetate labeled with tritiated thymidine was administered topically to one eye of 58 patients shortly before elective cataract extraction. An aqueous humor sample was aspirated at varying intervals and its corticosteroid content was determined. Peak drug concentration in aqueous humor was 1.13 mug/ml, which occurred 30 to 45 minutes after instillation of the medication. Substantial quantitites of corticosteroid were found in the aqueous humor five minutes after drug administration. The area under the drug concentration in aqueous humor-vs-time curve (a measure of the drug's bioavailability in aqueous humor) was 88 mug min/ml, and its half-life in human aqueous humor was 28 minutes. None of these values were significantly different from the comparable values in rabbit eyes.
H M Leibowitz, and
A R Berrospi, and
A Kupferman, and
G V Restropo, and
V Galvis, and
J A Alvarez
October 2002,
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics,
H M Leibowitz, and
A R Berrospi, and
A Kupferman, and
G V Restropo, and
V Galvis, and
J A Alvarez
April 2011,
Antimicrobial agents and chemotherapy,
H M Leibowitz, and
A R Berrospi, and
A Kupferman, and
G V Restropo, and
V Galvis, and
J A Alvarez
May 1988,
Archives of ophthalmology (Chicago, Ill. : 1960),
H M Leibowitz, and
A R Berrospi, and
A Kupferman, and
G V Restropo, and
V Galvis, and
J A Alvarez
January 1989,
Eye (London, England),
H M Leibowitz, and
A R Berrospi, and
A Kupferman, and
G V Restropo, and
V Galvis, and
J A Alvarez
September 2022,
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H M Leibowitz, and
A R Berrospi, and
A Kupferman, and
G V Restropo, and
V Galvis, and
J A Alvarez
May 1994,
Ophthalmology,
H M Leibowitz, and
A R Berrospi, and
A Kupferman, and
G V Restropo, and
V Galvis, and
J A Alvarez
January 2007,
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H M Leibowitz, and
A R Berrospi, and
A Kupferman, and
G V Restropo, and
V Galvis, and
J A Alvarez
October 1982,
American journal of ophthalmology,
H M Leibowitz, and
A R Berrospi, and
A Kupferman, and
G V Restropo, and
V Galvis, and
J A Alvarez
January 2003,
Ophthalmic research,
H M Leibowitz, and
A R Berrospi, and
A Kupferman, and
G V Restropo, and
V Galvis, and
J A Alvarez
November 1969,
Archives of ophthalmology (Chicago, Ill. : 1960),
