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New cationic 99Tc/99Tc complexes formed with various symmetrical and asymmetrical vicinal dioximes of different carbon chain length (C5-C8) were synthesized by reduction of pertechnetate with BH4-, separated by HPLC and characterized by i.r./u.v./vis. spectroscopy, FAB mass spectrometry and electrophoresis. All complexes studied are trisdioximes containing boron as a constituent. Their lipophilicity, as assessed by the octanol/saline partition coefficient, ranges over almost four orders of magnitude. The myocardial uptake of the 99mTc complexes in mice proves to be lower than expected. The organ distributions are distinctly affected by the lipophilicity, the position of the dioxime group and the introduction of a terminal methoxy group.
K Schwochau, and
K H Linse, and
H J Steinmetz, and
L Astheimer
March 1974,
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K Schwochau, and
K H Linse, and
H J Steinmetz, and
L Astheimer
January 1990,
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K Schwochau, and
K H Linse, and
H J Steinmetz, and
L Astheimer
May 2012,
Nuclear medicine communications,
K Schwochau, and
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L Astheimer
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K Schwochau, and
K H Linse, and
H J Steinmetz, and
L Astheimer
January 1982,
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K Schwochau, and
K H Linse, and
H J Steinmetz, and
L Astheimer
January 2014,
Iranian journal of pharmaceutical research : IJPR,
K Schwochau, and
K H Linse, and
H J Steinmetz, and
L Astheimer
June 2009,
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K Schwochau, and
K H Linse, and
H J Steinmetz, and
L Astheimer
April 2010,
Nuclear medicine and biology,
K Schwochau, and
K H Linse, and
H J Steinmetz, and
L Astheimer
July 2012,
Inorganic chemistry,
K Schwochau, and
K H Linse, and
H J Steinmetz, and
L Astheimer
October 1995,
Nuclear medicine and biology,
