Biomaterial Database

[Thermolability at 56 degrees C of mouse IgE antibodies]. 1977

A Prouvost-Danon, and R Binaghi, and A Abadie

The heat inactivation at 56 degrees C of mouse IgE antibodies, measured by their PCA activity, was studied in various experimental conditions. Mouse IgE antibodies are partially protected against heat inactivation when previously diluted in sodium chloride or in phosphate buffer media. The protection is better at a higher dilution and molarity (phosphate 1M) and at pH 7. Heat inactivation is increased by the presence of reducing, alkylating and denaturating agents. Heat lability depends upon the concentration of serum proteins in the medium and is increased in presence of immunoglobulins.

UI	MeSH Term	Description	Entries
D007073	Immunoglobulin E	An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).	IgE
D006358	Hot Temperature	Presence of warmth or heat or a temperature notably higher than an accustomed norm.	Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000906	Antibodies	Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus