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A group of 220 patients with mycosis fungoides (MF) and other lymphomatous diseases was treated with sustained topical applications of dilute aqueous solutions of mechlorethamine hydrochloride for intervals ranging in excess of seven years. Response to treatment, immunologic responsiveness, and subsequent course and survival were inversely related to magnitude of disease at time of starting treatment. Relapses were common and in most instances were related to failure to maintenance of topical therapy rather than to drug resistance. In selected patients topical therapy with an analog of mechlorethamine (nor-mechlorethamine) and with topical immunogenic agents provided additional improvement.
E C Vonderheid, and
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W C Johnson, and
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E C Vonderheid, and
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D A Grekin, and
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January 1977,
Bulletin du cancer,
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D A Grekin, and
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January 1978,
Dermatologica,
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December 1984,
Archives of dermatology,
E C Vonderheid, and
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International journal of dermatology,
E C Vonderheid, and
E J Van Scott, and
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July 1975,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
E C Vonderheid, and
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November 1977,
The British journal of dermatology,
E C Vonderheid, and
E J Van Scott, and
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Actas dermo-sifiliograficas,
E C Vonderheid, and
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S O Asbell
January 1985,
International journal of clinical pharmacology research,
E C Vonderheid, and
E J Van Scott, and
W C Johnson, and
D A Grekin, and
S O Asbell
January 1977,
Dermatologische Monatschrift,
