-transparent.png){kind=logo}
Cultured human skin fibroblasts from healthy donors were irradiated with 180 kJ.m-2 ultraviolet (UV) A (320-400 nm) and assayed for thiobarbituric acid-reactive substances (TBARS), taken as an indicator of lipid peroxidation. Antioxidant defenses, including total glutathione (GSH) levels, superoxide dismutase (SOD), glutathione peroxidase (GSHPx), and catalase (Cat) activities were simultaneously assayed before and after irradiation. For the various donors, with different activities of these antioxidant systems before irradiation, TBARS correlated positively with SOD activity and negatively with Cat activity, whereas no correlation with GSH level or GSHPx activity was found. These data support the view that O2- is generated by UVA irradiation. They also suggest that H2O2, arising from O2- dismutation by SOD is not completely removed by Cat. Thus, the sensitivity of human fibroblasts to UVA-induced lipid peroxidation depends on a balance between SOD and Cat activities. After UVA irradiation, Cat activity was strongly inhibited, whereas GSH level was slightly decreased. By contrast, GSHPx and SOD activity remained unchanged after UVA irradiation.
A Moysan, and
I Marquis, and
F Gaboriau, and
R Santus, and
L Dubertret, and
P Morlière
January 1995,
Archives of dermatological research,
A Moysan, and
I Marquis, and
F Gaboriau, and
R Santus, and
L Dubertret, and
P Morlière
August 1998,
European journal of biochemistry,
A Moysan, and
I Marquis, and
F Gaboriau, and
R Santus, and
L Dubertret, and
P Morlière
September 1995,
Free radical biology & medicine,
A Moysan, and
I Marquis, and
F Gaboriau, and
R Santus, and
L Dubertret, and
P Morlière
July 1991,
Biochimica et biophysica acta,
A Moysan, and
I Marquis, and
F Gaboriau, and
R Santus, and
L Dubertret, and
P Morlière
January 1995,
Photodermatology, photoimmunology & photomedicine,
A Moysan, and
I Marquis, and
F Gaboriau, and
R Santus, and
L Dubertret, and
P Morlière
January 1995,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
A Moysan, and
I Marquis, and
F Gaboriau, and
R Santus, and
L Dubertret, and
P Morlière
October 1990,
Toxicology,
A Moysan, and
I Marquis, and
F Gaboriau, and
R Santus, and
L Dubertret, and
P Morlière
January 2012,
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine,
A Moysan, and
I Marquis, and
F Gaboriau, and
R Santus, and
L Dubertret, and
P Morlière
January 2002,
Vestnik oftalmologii,
A Moysan, and
I Marquis, and
F Gaboriau, and
R Santus, and
L Dubertret, and
P Morlière
November 1989,
Hepatology (Baltimore, Md.),
