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The excision of 7-bromomethylbenz[a]anthracene--DNA adducts was studied in two cell lines (HeLa S-3 and Chinese hamster V-79379A). In both cell lines, carcinogen-modified adenine residues were excised more readily than the modified guanine residues and the percentage of the total products excised decreased after treatment with higher concentrations of carcinogen. At the highest concentrations used in the Chinese hamster cells, neither DNA synthesis nor excision was detected. The lowest concentration used for these cells permitted almost 100% survival and all the DNA was replicated in a 30-h interval even though 50% of the initial damage was still present. The two- to threefold lower sensitivity of the Chinese hamster cells (compared with the Hela cells) to the carcinogen is attributed to this capacity for replication of DNA on a damaged template since the two cell lines' capacities for excision of the chemical damage were found to be comparable.
A Dipple, and
J J Roberts
December 1978,
Nucleic acids research,
A Dipple, and
J J Roberts
July 1971,
European journal of biochemistry,
A Dipple, and
J J Roberts
January 1972,
Biochimie,
A Dipple, and
J J Roberts
January 1982,
Proceedings of the National Academy of Sciences of the United States of America,
A Dipple, and
J J Roberts
November 1972,
Biochimica et biophysica acta,
A Dipple, and
J J Roberts
March 1984,
Somatic cell and molecular genetics,
A Dipple, and
J J Roberts
July 1971,
European journal of biochemistry,
A Dipple, and
J J Roberts
November 1979,
Nucleic acids research,
A Dipple, and
J J Roberts
November 1971,
Biochemistry,
A Dipple, and
J J Roberts
July 1973,
European journal of biochemistry,
