-transparent.png){kind=logo}
In vivo studies of beta-cell secretory function have demonstrated the existence of rapid insulin oscillations of small amplitude recurring every 8-15 min in normal subjects. This study evaluated the effects of pancreas transplant on rapid insulin oscillations. Samples for glucose, insulin, and C-peptide were drawn during constant glucose infusion at 2-min intervals for 90 min from six successful Px patients with type I diabetes mellitus, from six normal nondiabetic control subjects, and from three Kx subjects. A computerized algorithm (ULTRA) was used for pulse detection. In the Px group, the average insulin pulse period was significantly shorter than in both the control and Kx groups (Px 8.1 +/- 0.5, control 12.5 +/- 0.7, Kx 12.4 +/- 0.5 min, P < 0.0005). By contrast, the C-peptide pulse periods (Px 16.8 +/- 2.3, control 14.7 +/- 1.2, Kx 15.3 +/- 1.5 min) were similar in the three groups. Spectral analysis confirmed that the frequency of the insulin pulses was increased in the Px group. The absolute amplitude of the insulin pulses was greater in the Px group (P < 0.001) while the amplitude of the C-peptide pulses did not differ between the groups. Cross-correlation analysis demonstrated maximal correlation coefficients at a lag of 0 min between insulin and C-peptide (control r = 0.33, P < 0.0001; Kx r = 0.17, P = 0.06) and between insulin and glucose (control r = 0.21, P < 0.001; Kx r = 0.20, P < 0.02) in the control and Kx groups, respectively, whereas no significant correlations were observed at any lag in the Px group.(ABSTRACT TRUNCATED AT 250 WORDS)
N M O'Meara, and
J Sturis, and
J D Blackman, and
M M Byrne, and
J B Jaspan, and
D C Roland, and
J R Thistlethwaite, and
K S Polonsky
December 1990,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
N M O'Meara, and
J Sturis, and
J D Blackman, and
M M Byrne, and
J B Jaspan, and
D C Roland, and
J R Thistlethwaite, and
K S Polonsky
July 2001,
Bulletin of mathematical biology,
N M O'Meara, and
J Sturis, and
J D Blackman, and
M M Byrne, and
J B Jaspan, and
D C Roland, and
J R Thistlethwaite, and
K S Polonsky
January 2009,
Molecular and cellular endocrinology,
N M O'Meara, and
J Sturis, and
J D Blackman, and
M M Byrne, and
J B Jaspan, and
D C Roland, and
J R Thistlethwaite, and
K S Polonsky
December 1994,
The Journal of clinical endocrinology and metabolism,
N M O'Meara, and
J Sturis, and
J D Blackman, and
M M Byrne, and
J B Jaspan, and
D C Roland, and
J R Thistlethwaite, and
K S Polonsky
December 1970,
The Journal of endocrinology,
N M O'Meara, and
J Sturis, and
J D Blackman, and
M M Byrne, and
J B Jaspan, and
D C Roland, and
J R Thistlethwaite, and
K S Polonsky
September 1996,
Diabetic medicine : a journal of the British Diabetic Association,
N M O'Meara, and
J Sturis, and
J D Blackman, and
M M Byrne, and
J B Jaspan, and
D C Roland, and
J R Thistlethwaite, and
K S Polonsky
May 1993,
The American journal of physiology,
N M O'Meara, and
J Sturis, and
J D Blackman, and
M M Byrne, and
J B Jaspan, and
D C Roland, and
J R Thistlethwaite, and
K S Polonsky
April 1998,
The American journal of physiology,
N M O'Meara, and
J Sturis, and
J D Blackman, and
M M Byrne, and
J B Jaspan, and
D C Roland, and
J R Thistlethwaite, and
K S Polonsky
October 1989,
The American journal of physiology,
N M O'Meara, and
J Sturis, and
J D Blackman, and
M M Byrne, and
J B Jaspan, and
D C Roland, and
J R Thistlethwaite, and
K S Polonsky
August 1971,
Prensa medica argentina,
