-transparent.png){kind=logo}
To investigate the high prevalence among infants of antibodies to Bordetella pertussis adenylate cyclase toxin (ACT), cord-blood sera were examined for antibodies to ACT, filamentous hemagglutinin (FHA) and pertussis toxin (PT) using immunoblot analysis. Antibodies reactive with ACT were the most prevalent in neonatal sera. Similar reactivity of IgG with ACT was found in each sample of a given neonatal-maternal pair, yet IgM reactive with ACT was virtually absent in neonatal sera, suggesting that antibodies to ACT are maternally derived. Antibodies to ACT might come from infection or childhood vaccination of the mothers since pertussis vaccines from all US manufacturers elicited antibodies to ACT in mice. Alternatively, these antibodies may have been elicited by a cross-reactive antigen such as Escherichia coli alpha-hemolysin, since all of the neonatal and maternal sera contained antibodies reactive with alpha-hemolysin.
J L Arciniega, and
E L Hewlett, and
K M Edwards, and
D L Burns
November 1989,
Trends in biochemical sciences,
J L Arciniega, and
E L Hewlett, and
K M Edwards, and
D L Burns
May 1999,
Infection and immunity,
J L Arciniega, and
E L Hewlett, and
K M Edwards, and
D L Burns
December 2000,
Infection and immunity,
J L Arciniega, and
E L Hewlett, and
K M Edwards, and
D L Burns
April 1993,
Zentralblatt fur Bakteriologie : international journal of medical microbiology,
J L Arciniega, and
E L Hewlett, and
K M Edwards, and
D L Burns
January 1991,
FEBS letters,
J L Arciniega, and
E L Hewlett, and
K M Edwards, and
D L Burns
October 2002,
Toxicon : official journal of the International Society on Toxinology,
J L Arciniega, and
E L Hewlett, and
K M Edwards, and
D L Burns
August 1984,
The Journal of infectious diseases,
J L Arciniega, and
E L Hewlett, and
K M Edwards, and
D L Burns
June 2005,
Archives of biochemistry and biophysics,
J L Arciniega, and
E L Hewlett, and
K M Edwards, and
D L Burns
October 1994,
Science (New York, N.Y.),
J L Arciniega, and
E L Hewlett, and
K M Edwards, and
D L Burns
June 1999,
Infection and immunity,
