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Soluble protein extracts from adult Ancylostoma hookworms were found to contain an anticoagulant activity that markedly prolonged both the prothrombin time (PT) and partial thromboplastin time (PTT). By chromogenic peptide substrate and clotting time assays, the anticoagulant activity was attributed to a specific inhibitor of clotting factor Xa. The hookworm anticoagulant was partially purified by ion-exchange column chromatography. Those column fractions containing anti-Xa activity by chromogenic assay also prolonged the PT and PTT as well as the factor X (Stypven) clotting time. These data suggest that this potent factor Xa inhibitor is a major anticoagulant from the adult Ancylostoma hookworm.
M Cappello, and
L P Clyne, and
P McPhedran, and
P J Hotez
June 1995,
Proceedings of the National Academy of Sciences of the United States of America,
M Cappello, and
L P Clyne, and
P McPhedran, and
P J Hotez
February 2002,
The Journal of biological chemistry,
M Cappello, and
L P Clyne, and
P McPhedran, and
P J Hotez
June 2001,
Molecular and biochemical parasitology,
M Cappello, and
L P Clyne, and
P McPhedran, and
P J Hotez
January 2020,
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases,
M Cappello, and
L P Clyne, and
P McPhedran, and
P J Hotez
June 2009,
FEBS letters,
M Cappello, and
L P Clyne, and
P McPhedran, and
P J Hotez
May 1998,
Thrombosis and haemostasis,
M Cappello, and
L P Clyne, and
P McPhedran, and
P J Hotez
October 2009,
Revue medicale de Liege,
M Cappello, and
L P Clyne, and
P McPhedran, and
P J Hotez
February 1991,
Archives of biochemistry and biophysics,
M Cappello, and
L P Clyne, and
P McPhedran, and
P J Hotez
October 1987,
Thrombosis research,
M Cappello, and
L P Clyne, and
P McPhedran, and
P J Hotez
February 2018,
P & T : a peer-reviewed journal for formulary management,
