-transparent.png){kind=logo}
Calcium and gla-protein content are increased in the calcifications of cardiac bioprostheses. Such calcifications are more frequent during growth, pregnancy and renal failure when bone gla-protein levels are elevated. We investigated whether bone gla-protein and other markers of calcium metabolism play a role in bioprostheses calcifications. Forty-seven patients were separated into 2 groups according to the presence (group A, n = 9) or absence (group B, n = 38) of bioprostheses calcifications, as assessed by echo-doppler and surgery. Plasma levels of calcium, phosphorus, magnesium, creatinine and alkaline phosphatases were measured by standard laboratory methods, parathormone and those of bone gla-protein by specific radioimmunoassays. Results (mean +/- SEM) were compared (group A versus group B, P < 0.01) using Student's test and one-factor variance analysis (ANOVA). Age was similar in both group (53 +/- 12.9 vs 50 +/- 12.3 yrs), whereas duration of implant was greater in group A (104 +/- 12.4 vs 66 +/- 6.5 months, P < 0.01). No statistically significant difference was found between group A and B concerning biochemical and/or hormonal markers of calcium metabolism. These negative results merit to be discussed, and further studies will be needed to explore the potential role of circulating bone gla-protein in bioprostheses calcifications.
D Farge, and
M Shen, and
F Castaldo, and
J P Gardin, and
S Carpentier, and
M Cambillau, and
A C Puaud, and
A Carpentier
January 1991,
Medicina clinica,
D Farge, and
M Shen, and
F Castaldo, and
J P Gardin, and
S Carpentier, and
M Cambillau, and
A C Puaud, and
A Carpentier
January 1962,
Journal belge de medecine physique et de rhumatologie. Belgisch tijdschrift voor fysische geneeskunde en reumatologie,
D Farge, and
M Shen, and
F Castaldo, and
J P Gardin, and
S Carpentier, and
M Cambillau, and
A C Puaud, and
A Carpentier
February 1992,
Medicina clinica,
D Farge, and
M Shen, and
F Castaldo, and
J P Gardin, and
S Carpentier, and
M Cambillau, and
A C Puaud, and
A Carpentier
January 1987,
Revue medicale de Bruxelles,
D Farge, and
M Shen, and
F Castaldo, and
J P Gardin, and
S Carpentier, and
M Cambillau, and
A C Puaud, and
A Carpentier
January 1990,
The Annals of thoracic surgery,
D Farge, and
M Shen, and
F Castaldo, and
J P Gardin, and
S Carpentier, and
M Cambillau, and
A C Puaud, and
A Carpentier
November 1981,
Zhonghua wai ke za zhi [Chinese journal of surgery],
D Farge, and
M Shen, and
F Castaldo, and
J P Gardin, and
S Carpentier, and
M Cambillau, and
A C Puaud, and
A Carpentier
September 1989,
The Annals of thoracic surgery,
D Farge, and
M Shen, and
F Castaldo, and
J P Gardin, and
S Carpentier, and
M Cambillau, and
A C Puaud, and
A Carpentier
January 1977,
Medical instrumentation,
D Farge, and
M Shen, and
F Castaldo, and
J P Gardin, and
S Carpentier, and
M Cambillau, and
A C Puaud, and
A Carpentier
January 1969,
Revista argentina de urologia y nefrologia,
D Farge, and
M Shen, and
F Castaldo, and
J P Gardin, and
S Carpentier, and
M Cambillau, and
A C Puaud, and
A Carpentier
May 1962,
Revue francaise d'etudes cliniques et biologiques,
