Biomaterial Database

[Toxic megacolon in pseudomembranous colitis. Complicated course of antibiotic-induced Clostridium difficile colitis]. 1993

G Rexroth

Medizinische Klinik, Nordwest der Stiftung Hospital zum heiligen Geist, Frankfurt/M.

We report on a patient with antibiotic-induced pseudomembranous colitis aggravated by toxic megacolon. Colonoscopy not only rapidly permits the diagnosis to be established, but the relief of pressure achieved simultaneously also has a therapeutic effect. If treatment comprising parenteral fluid and electrolyte replacement in combination with oral vancomycin fails to effect an improvement, surgery becomes necessary. Current recommendations for treatment are discussed on the basis of a review of the literature. However, a major preventive measure remains the rational use of antibiotics.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008532	Megacolon, Toxic	An acute form of MEGACOLON, severe pathological dilatation of the COLON. It is associated with clinical conditions such as ULCERATIVE COLITIS; CROHN DISEASE; AMEBIC DYSENTERY; or CLOSTRIDIUM ENTEROCOLITIS.	Toxic Megacolon
D002981	Clindamycin	An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.	7-Chloro-7-deoxylincomycin,Chlolincocin,Chlorlincocin,Cleocin,Clindamycin Hydrochloride,Clindamycin Monohydrochloride,Clindamycin Monohydrochloride, Monohydrate,Dalacin C,7 Chloro 7 deoxylincomycin,Hydrochloride, Clindamycin,Monohydrate Clindamycin Monohydrochloride,Monohydrochloride, Clindamycin,Monohydrochloride, Monohydrate Clindamycin
D003131	Combined Modality Therapy	The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.	Multimodal Treatment,Therapy, Combined Modality,Combined Modality Therapies,Modality Therapies, Combined,Modality Therapy, Combined,Multimodal Treatments,Therapies, Combined Modality,Treatment, Multimodal,Treatments, Multimodal
D004761	Enterocolitis, Pseudomembranous	An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.	Antibiotic-Associated Colitis,Clostridium Enterocolitis,Colitis, Pseudomembranous,Enteritis, Pseudomembranous,Pseudomembranous Colitis,Pseudomembranous Enteritis,Pseudomembranous Enterocolitis,Antibiotic Associated Colitis,Colitis, Antibiotic-Associated
D005440	Fluid Therapy	Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.	Oral Rehydration Therapy,Rehydration,Rehydration, Oral,Oral Rehydration,Rehydration Therapy, Oral,Therapy, Fluid,Therapy, Oral Rehydration,Fluid Therapies,Oral Rehydration Therapies,Oral Rehydrations,Rehydration Therapies, Oral,Rehydrations,Rehydrations, Oral,Therapies, Fluid,Therapies, Oral Rehydration
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D012812	Sigmoidoscopy	Endoscopic examination, therapy or surgery of the sigmoid flexure.	Proctosigmoidoscopy,Sigmoidoscopic Surgical Procedures,Surgical Procedures, Sigmoidoscopic,Sigmoidoscopic Surgery,Surgery, Sigmoidoscopic,Procedure, Sigmoidoscopic Surgical,Procedures, Sigmoidoscopic Surgical,Proctosigmoidoscopies,Sigmoidoscopic Surgeries,Sigmoidoscopic Surgical Procedure,Sigmoidoscopies,Surgeries, Sigmoidoscopic,Surgical Procedure, Sigmoidoscopic
D012852	Sinusitis	Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.	Sinus Infections,Infection, Sinus,Infections, Sinus,Sinus Infection,Sinusitides