-transparent.png){kind=logo}
A series of 4,5-diamino-substituted-1,2-benzoquinones were prepared from catechol and the corresponding secondary amines in high yield in a single step using copper complex formation to stabilize the intermediate. The cytotoxicity of the products under various conditions was evaluated using the EMT-6 mammary carcinoma cell line, and antitumor activity was tested in the L1210 murine leukemia. The 4,5-diaziridinyl-1,2-benzoquinone was a more potent cytotoxic agent than diaziquone (AZQ) and was very effective against the L1210 leukemia. The azetidine, pyrrolidine, and diethylamine derivatives were not effective antitumor agents.
Related Publications
Z D Huang, and
Y N Chen, and
K Menon, and
B A Teicher
March 2009,
Acta crystallographica. Section E, Structure reports online,
Z D Huang, and
Y N Chen, and
K Menon, and
B A Teicher
November 1964,
Comptes rendus hebdomadaires des seances de l'Academie des sciences,
Z D Huang, and
Y N Chen, and
K Menon, and
B A Teicher
June 1986,
Chemical & pharmaceutical bulletin,
Z D Huang, and
Y N Chen, and
K Menon, and
B A Teicher
May 1977,
Die Pharmazie,
Z D Huang, and
Y N Chen, and
K Menon, and
B A Teicher
December 2006,
Bioorganic & medicinal chemistry,
Z D Huang, and
Y N Chen, and
K Menon, and
B A Teicher
May 2002,
Archiv der Pharmazie,
Z D Huang, and
Y N Chen, and
K Menon, and
B A Teicher
October 1980,
Gan,
Z D Huang, and
Y N Chen, and
K Menon, and
B A Teicher
November 1973,
Journal of medicinal chemistry,
Z D Huang, and
Y N Chen, and
K Menon, and
B A Teicher
October 1986,
Journal of medicinal chemistry,
Z D Huang, and
Y N Chen, and
K Menon, and
B A Teicher
January 2005,
Bioorganic & medicinal chemistry letters,
