Biomaterial Database

The effect of hypovolemic shock and reperfusion on the hepatic oxygen supply-uptake relationship in the dog. 1995

G Kinoshita, and M Washizu, and S Motoyoshi, and E M Breznock

Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University, Tokyo, Japan.

The hepatic oxygen supply-uptake relationship was investigated during hypovolemic shock using a right heart bypass technique. The results were dissimilar to those previously reported in that the ratio of liver oxygen delivery to systemic oxygen delivery was significantly decreased during shock. The decreased ratio was due to a significant decrease in the portal venous oxygen delivery when compared to the decrease in the systemic oxygen delivery. The decrease in portal venous oxygen delivery was caused not only by the decrease in portal venous blood flow, but also by the decrease in oxygen content of portal blood. The ratio of hepatic arterial oxygen delivery, on the other hand, was significantly increased during shock. Hypovolemic shock increased the liver oxygen extraction ratio to nearly 100% of the pre-shock value. These findings suggest a hepatic protective mechanism for matching oxygen uptake to rising hepatic oxygen requirements. Liver oxygen delivery returned to pre-shock value after correction of hypovolemia primarily due to a significant increase in hepatic arterial oxygen delivery. A significant negative correlation between the liver oxygen extraction ratio and the oxygen content of hepatic venous blood was observed. The hepatic venous oxygen content appears to be a simple and appropriate index of liver oxygenation in clinical medicine because it is difficult to evaluate the liver oxygen extraction ratio directly.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008102	Liver Circulation	The circulation of BLOOD through the LIVER.	Hepatic Circulation,Circulation, Liver,Circulation, Hepatic
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D010313	Partial Pressure	The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Partial Pressures,Pressure, Partial,Pressures, Partial
D011169	Portal Vein	A short thick vein formed by union of the superior mesenteric vein and the splenic vein.	Portal Veins,Vein, Portal,Veins, Portal
D012039	Regional Blood Flow	The flow of BLOOD through or around an organ or region of the body.	Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D012044	Regression Analysis	Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.	Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006499	Hepatic Artery	A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.	Arteries, Hepatic,Artery, Hepatic,Hepatic Arteries

Related Publications

G Kinoshita, and M Washizu, and S Motoyoshi, and E M Breznock

The relationship between oxygen supply and oxygen uptake in septic shock: the possible role of endotoxin.

January 1989, Progress in clinical and biological research,

G Kinoshita, and M Washizu, and S Motoyoshi, and E M Breznock

Hepatic oxygen supply-uptake relationship and metabolism during anesthesia in miniature pigs.

May 1990, Anesthesiology,

G Kinoshita, and M Washizu, and S Motoyoshi, and E M Breznock

The relationship between oxygen demand, oxygen uptake, and oxygen supply.

January 1990, Intensive care medicine,

G Kinoshita, and M Washizu, and S Motoyoshi, and E M Breznock

The effect of hepatic vascular exclusion on hepatic blood flow and oxygen supply--uptake ratio in the pig.

October 1997, European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie,

G Kinoshita, and M Washizu, and S Motoyoshi, and E M Breznock

Effect of thromboxane receptor blockade on oxygen supply/consumption variables during reperfusion in the anesthetized dog.

June 1990, The Journal of pharmacology and experimental therapeutics,

G Kinoshita, and M Washizu, and S Motoyoshi, and E M Breznock

Hypovolemic shock in the military working dog.

May 1982, Military medicine,

G Kinoshita, and M Washizu, and S Motoyoshi, and E M Breznock

The effect of liver denervation on hepatic hemodynamics during hypovolemic shock in swine.

January 1992, Hepatology (Baltimore, Md.),

G Kinoshita, and M Washizu, and S Motoyoshi, and E M Breznock

Dopamine and hepatic oxygen supply-demand relationship.

August 1990, Canadian journal of physiology and pharmacology,