BIOMAT Database Logo BIOMAT Database Logo

Intra-arterial chemotherapy with cisplatin followed by radical radiotherapy for locally advanced cervical cancer. 1995

H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Department of Radiology, Niigata University School of Medicine, Japan.

Locally advanced cervical cancer has a dismal prognosis, with a high local failure rate and a poor survival rate. To improve the cure rate for advanced carcinoma of the cervix, we initiated a study of intra-arterial (I-A) chemotherapy with cisplatin via the uterine artery prior to definitive radiotherapy. I-A chemotherapy via the internal iliac artery has been used to treat advanced cervical cancer; however, access by way of the uterine artery has not been tested for this purpose. Thirty-four patients with central tumor > or = 5 cm in anteroposterior diameter observed on CT scans were treated with I-A chemotherapy. I-A chemotherapy consisted of unilateral catheterization of the uterine artery using 120 mg/m2 cisplatin. After assessment of I-A chemotherapy, all but 3 patients were treated with a combination of whole-pelvis external irradiation and intracavitary irradiation. The 3 patients underwent external radiotherapy alone. Twenty-seven of 34 patients treated were evaluable for response to I-A chemotherapy. Eleven patients (41%) experienced a partial response. Seventy-six percent of the 34 patients treated with I-A chemotherapy followed by radiotherapy exhibited a complete response by the end of treatment. Toxicity was well tolerated and no death due to treatment occurred. The 2- and 5-year actuarial survival rates were 64 and 55%, respectively. The crude incidences of pelvic recurrence and distant metastasis observed at a median follow-up of 54 months were both 47%. This study for locally advanced cervical cancer suggests there is benefit to be derived from our I-A chemotherapy followed by radical radiotherapy.

UI MeSH Term Description Entries
D007261 Infusions, Intra-Arterial Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease. Infusions, Regional Arterial,Infusions, Intra Arterial,Infusions, Intraarterial,Arterial Infusion, Intra,Arterial Infusion, Regional,Arterial Infusions, Intra,Arterial Infusions, Regional,Infusion, Intra Arterial,Infusion, Intra-Arterial,Infusion, Intraarterial,Infusion, Regional Arterial,Intra Arterial Infusion,Intra Arterial Infusions,Intra-Arterial Infusion,Intra-Arterial Infusions,Intraarterial Infusion,Intraarterial Infusions,Regional Arterial Infusion,Regional Arterial Infusions
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009364 Neoplasm Recurrence, Local The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site. Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D002583 Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX. Cancer of Cervix,Cancer of the Cervix,Cancer of the Uterine Cervix,Cervical Cancer,Cervical Neoplasms,Cervix Cancer,Cervix Neoplasms,Neoplasms, Cervical,Neoplasms, Cervix,Uterine Cervical Cancer,Cancer, Cervical,Cancer, Cervix,Cancer, Uterine Cervical,Cervical Cancer, Uterine,Cervical Cancers,Cervical Neoplasm,Cervical Neoplasm, Uterine,Cervix Neoplasm,Neoplasm, Cervix,Neoplasm, Uterine Cervical,Uterine Cervical Cancers,Uterine Cervical Neoplasm
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D003131 Combined Modality Therapy The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used. Multimodal Treatment,Therapy, Combined Modality,Combined Modality Therapies,Modality Therapies, Combined,Modality Therapy, Combined,Multimodal Treatments,Therapies, Combined Modality,Treatment, Multimodal,Treatments, Multimodal
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Neoadjuvant intraarterial chemotherapy followed by radical hysterectomy and/or radiotherapy for locally advanced cervical cancer.
May 1998, Gynecologic oncology,
H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Neoadjuvant chemotherapy plus radical surgery followed by chemotherapy in locally advanced cervical cancer.
November 2012, Gynecologic oncology,
H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Neoadjuvant chemotherapy with weekly cisplatin and paclitaxel followed by chemoradiation for locally advanced cervical cancer.
January 2023, BMC cancer,
H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer.
April 1999, The New England journal of medicine,
H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Intra-arterial neoadjuvant chemotherapy followed by radical surgery and radiotherapy for stage IIb cervical carcinoma.
January 1997, Anticancer research,
H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Prognostic factors for locally advanced cervical cancer treated with neoadjuvant intravenous and transuterine arterial chemotherapy followed by radical hysterectomy.
October 2013, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society,
H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Radiotherapy combined with transcatheter arterial infusion chemotherapy for locally advanced cervical cancer.
January 1998, Acta oncologica (Stockholm, Sweden),
H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Therapeutic value of neoadjuvant intra-arterial chemotherapy (cisplatin) and irradiation for locally advanced uterine cervical cancer.
June 1997, Gynecologic oncology,
H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Survival benefits of neoadjuvant chemotherapy followed by radical surgery versus radiotherapy in locally advanced chemoresistant cervical cancer.
August 2006, Journal of Korean medical science,
H Sueyama, and M Nakano, and K Sakumoto, and T Toita, and Y Takizawa, and H Moromizato, and Y Kakihana, and A Kushi, and H Moromizato, and M Higashi
Combination chemotherapy followed by surgery or radiotherapy in patients with locally advanced cervical cancer.
June 1987, British journal of obstetrics and gynaecology,
Copied contents to your clipboard!