-transparent.png){kind=logo}
We investigated the effects of diclofenac sodium and indomethacin on the proliferation of and collagen synthesis by lens epithelial cells (LECs) of human cataracts in culture. The anterior capsule with attached LECs, obtained by anterior capsulotomy during cataract surgery, was cultured directly without cell dispersion. When the culture became almost confluent, diclofenac sodium or indomethacin at various concentrations was added to the incubation medium. The incorporation of 3H-thymidine and 3H-proline into the LECs was measured after the cells were labeled with these radioactive materials. Both drugs greatly suppressed the incorporation of 3H-thymidine and of 3H-proline, indicating that they inhibit cell division and collagen synthesis by LECs. Both drugs may help prevent posterior capsule opacification.
O Nishi, and
K Nishi, and
T Fujiwara, and
E Shirasawa
November 2010,
Yan ke xue bao = Eye science,
O Nishi, and
K Nishi, and
T Fujiwara, and
E Shirasawa
March 1997,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
O Nishi, and
K Nishi, and
T Fujiwara, and
E Shirasawa
January 2004,
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft,
O Nishi, and
K Nishi, and
T Fujiwara, and
E Shirasawa
January 2004,
Japanese journal of ophthalmology,
O Nishi, and
K Nishi, and
T Fujiwara, and
E Shirasawa
January 2017,
Current eye research,
O Nishi, and
K Nishi, and
T Fujiwara, and
E Shirasawa
November 2014,
Biochemical and biophysical research communications,
O Nishi, and
K Nishi, and
T Fujiwara, and
E Shirasawa
June 2018,
Experimental and therapeutic medicine,
O Nishi, and
K Nishi, and
T Fujiwara, and
E Shirasawa
August 1991,
European journal of cell biology,
O Nishi, and
K Nishi, and
T Fujiwara, and
E Shirasawa
January 2004,
Journal of clinical periodontology,
O Nishi, and
K Nishi, and
T Fujiwara, and
E Shirasawa
November 1995,
Investigative ophthalmology & visual science,
