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The aim of the study was to evaluate susceptibility to ciprofloxacin of bacteria species isolated from different specimens of clinical materials. The investigated strains (830) were identified using conventional methods. The antibacterial activity of ciprofloxacin was studied by the method of drug dilution in Mueller-Hinton agar. Among aerobic bacteria, only 5 strains (0.6%) were resistant to ciprofloxacin in concentration 4 micrograms/ml; two belonged to E. coli species, two to S. aureus and one was a Streptococcus group B., Corynebacterium sp. MIC90 = 0.12 microgram/ml turned out to be most resistant, next, Gram-negative rods MIC90 = 0.5 microgram/ml, coagulase-negative and positive staphylococci and Neisseria sp. MIC90 = 1.0 microgram/ml. Enterococcus faecalis and anaerobes were the least susceptible to ciprofloxacin. Their MIC90 was 2 and 16 micrograms/ml respectively. Among 20 anaerobic strains, up to 10 were resistant to ciprofloxacin, mainly from Bacteroides and Clostridium genus.
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