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OBJECTIVE To explore dopaminergic mechanisms in alcohol dependence, the authors measured plasma homovanillic acid (HVA) in recently detoxified alcohol-dependent men. METHODS Plasma HVA was measured in 83 male patients with a diagnosis of alcohol dependence who had maintained documented abstinence for at least 3 weeks and in 69 healthy male comparison subjects. RESULTS The alcoholic patients as a group had significantly lower levels of plasma HVA than the comparison subjects. This difference was not influenced by any other measured covariate, including a family history of alcohol dependence. CONCLUSIONS These results imply that factors such as alcohol dependence should be taken into account in future studies of plasma HVA.
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Y Chae, and
P G Isbell, and
F Petty
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M K Fulton, and
G Kramer, and
F G Moeller, and
Y Chae, and
P G Isbell, and
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M K Fulton, and
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M K Fulton, and
G Kramer, and
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M K Fulton, and
G Kramer, and
F G Moeller, and
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M K Fulton, and
G Kramer, and
F G Moeller, and
Y Chae, and
P G Isbell, and
F Petty
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