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We have recently localized the gene for congenital nephrotic syndrome of the Finnish type (CNF) to chromosome 19q12-13.1. On the basis of observed recombination events, the gene was localized between markers D19S416/D19S425/D19S213/D19S208/D19S191 and D19S224. Here we have extended the mapping efforts, on the basis of a detailed physical map of the region. By means of three new polymorphic markers--D19S608, D19S609, and D19S610--developed in this study, the critical candidate region could be further restricted. Significant linkage disequilibrium was observed with markers D19S610, D19S608, D19S224, and D19S220, the strongest allelic association being 84% with marker D19S610 at 19q13.1. This suggests that the CNF gene locus lies in close proximity to marker D19S610. Combination of the informative markers revealed four main haplotype categories. Different geographic distribution was observed between these haplotype groups when they were placed on the map of finland according to the birthplaces of grandparents.
M Männikkö, and
M Kestailä, and
C Holmberg, and
R Norio, and
M Ryynänen, and
A Olsen, and
L Peltonen, and
K Tryggvason
December 2013,
Animal genetics,
M Männikkö, and
M Kestailä, and
C Holmberg, and
R Norio, and
M Ryynänen, and
A Olsen, and
L Peltonen, and
K Tryggvason
December 2009,
Genetics,
M Männikkö, and
M Kestailä, and
C Holmberg, and
R Norio, and
M Ryynänen, and
A Olsen, and
L Peltonen, and
K Tryggvason
January 2000,
American journal of human genetics,
M Männikkö, and
M Kestailä, and
C Holmberg, and
R Norio, and
M Ryynänen, and
A Olsen, and
L Peltonen, and
K Tryggvason
June 2018,
International ophthalmology,
M Männikkö, and
M Kestailä, and
C Holmberg, and
R Norio, and
M Ryynänen, and
A Olsen, and
L Peltonen, and
K Tryggvason
September 1997,
Cancer research,
M Männikkö, and
M Kestailä, and
C Holmberg, and
R Norio, and
M Ryynänen, and
A Olsen, and
L Peltonen, and
K Tryggvason
August 1994,
The Journal of investigative dermatology,
M Männikkö, and
M Kestailä, and
C Holmberg, and
R Norio, and
M Ryynänen, and
A Olsen, and
L Peltonen, and
K Tryggvason
January 1997,
Acta dermato-venereologica,
M Männikkö, and
M Kestailä, and
C Holmberg, and
R Norio, and
M Ryynänen, and
A Olsen, and
L Peltonen, and
K Tryggvason
December 2022,
Mammalian genome : official journal of the International Mammalian Genome Society,
M Männikkö, and
M Kestailä, and
C Holmberg, and
R Norio, and
M Ryynänen, and
A Olsen, and
L Peltonen, and
K Tryggvason
January 2002,
Human heredity,
M Männikkö, and
M Kestailä, and
C Holmberg, and
R Norio, and
M Ryynänen, and
A Olsen, and
L Peltonen, and
K Tryggvason
November 1994,
The Journal of investigative dermatology,
