-transparent.png){kind=logo}
Processing of the Plasmodium merozoite surface protein 1 (MSP-1) has been described for parasites maintained under in vitro conditions. We have now demonstrated, using CBA/Ca mice infected with Plasmodium chabaudi chabaudi AS, that MSP-1 processing also occurs in vivo. The major proteolytic cleavage sites and a processing scheme were deduced from N-terminal amino-acid sequences of the MSP-1 breakdown products. Comparison of MSP-1 processing in P. falciparum and P.c. chabaudi indicates a degree of conservation and in two cases the position of protease cleavage appears identical. Significant amounts of MSP-1 polypeptides are found in plasma during schizogony. Various aspects of MSP-1 processing including immunological and physiological reactions in the host during the critical period of schizogony can now be examined in vivo.
K P O'Dea, and
P G McKean, and
A Harris, and
K N Brown
July 1996,
Experimental parasitology,
K P O'Dea, and
P G McKean, and
A Harris, and
K N Brown
January 2003,
European journal of biochemistry,
K P O'Dea, and
P G McKean, and
A Harris, and
K N Brown
May 2003,
Vaccine,
K P O'Dea, and
P G McKean, and
A Harris, and
K N Brown
March 1997,
Molecular and biochemical parasitology,
K P O'Dea, and
P G McKean, and
A Harris, and
K N Brown
March 2009,
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases,
K P O'Dea, and
P G McKean, and
A Harris, and
K N Brown
April 2001,
Infection and immunity,
K P O'Dea, and
P G McKean, and
A Harris, and
K N Brown
July 1989,
Infection and immunity,
K P O'Dea, and
P G McKean, and
A Harris, and
K N Brown
January 1994,
Methods in cell biology,
K P O'Dea, and
P G McKean, and
A Harris, and
K N Brown
May 1999,
Infection and immunity,
K P O'Dea, and
P G McKean, and
A Harris, and
K N Brown
June 2021,
Science advances,
