[Small thyroid nodules and microcancers]. 1995

D Mellière

Thyroid nodules less than one centimetre in diameter raise the problem of differential diagnosis between a benign formation and cancer. The question is of major importance since nodules can be found in approximately one-half of the population. Fine-Needle Aspiration should be performed if the nodule is palpable. When cytologic diagnosis is not possible, the discovery of a small nodule in the thyroid gland is not an alarming finding in itself as long as the absence of involvement of the satellite nodes or other associated symptomatology is confirmed. We have operated 102 patients with differentiated microcancers with no metastasis other than local node involvement. All have been seen regularly for annual check-ups and only 2 have developed pulmonary and bone metastases with a fatal outcome. The prognosis of microcancers is thus much better than that of larger tumours since in a series of more than 500 cancers we have observed 5 and 10 year survivals of 96 and 92% respectively. In addition, unlike large tumours, small cancers of the thyroid are not anaplastic. We thus propose annual surveillance for patients with uncomplicated small nodules of the thyroid gland less than 2 cm in diameter. Complementary examinations should be limited. Conversely we operate the nodules exceeding 2 cm in order to reduce the frequency and severity of thyroid cancer. It should be recalled that neither clinical manifestations, echography, thyroglobulin, needle biopsy, nor any other diagnostic tool has been shown to have sufficient prognostic power to predict the benign nature of a voluminous nodule.

UI MeSH Term Description Entries
D008297 Male Males
D009364 Neoplasm Recurrence, Local The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site. Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013964 Thyroid Neoplasms Tumors or cancer of the THYROID GLAND. Cancer of Thyroid,Thyroid Cancer,Cancer of the Thyroid,Neoplasms, Thyroid,Thyroid Adenoma,Thyroid Carcinoma,Adenoma, Thyroid,Adenomas, Thyroid,Cancer, Thyroid,Cancers, Thyroid,Carcinoma, Thyroid,Carcinomas, Thyroid,Neoplasm, Thyroid,Thyroid Adenomas,Thyroid Cancers,Thyroid Carcinomas,Thyroid Neoplasm
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014463 Ultrasonography The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz. Echography,Echotomography,Echotomography, Computer,Sonography, Medical,Tomography, Ultrasonic,Ultrasonic Diagnosis,Ultrasonic Imaging,Ultrasonographic Imaging,Computer Echotomography,Diagnosis, Ultrasonic,Diagnostic Ultrasound,Ultrasonic Tomography,Ultrasound Imaging,Diagnoses, Ultrasonic,Diagnostic Ultrasounds,Imaging, Ultrasonic,Imaging, Ultrasonographic,Imaging, Ultrasound,Imagings, Ultrasonographic,Imagings, Ultrasound,Medical Sonography,Ultrasonic Diagnoses,Ultrasonographic Imagings,Ultrasound, Diagnostic,Ultrasounds, Diagnostic
D016606 Thyroid Nodule A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR). Nodule, Thyroid,Nodules, Thyroid,Thyroid Nodules

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