The biochemical and pharmacological activity of 9-benzyl-9-deazaguanine, a potent purine nucleoside phosphorylase (PNP) inhibitor. 1995

E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
Research Department, Ciba-Geigy Corp., Summit, NJ 07901, USA.

UI MeSH Term Description Entries
D007288 Inosine A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D011683 Purine-Nucleoside Phosphorylase An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1. Inosine Phosphorylase,Nicotinamide Riboside Phosphorylase,Purine Nucleoside Phosphorylases,Nucleoside Phosphorylases, Purine,Phosphorylase, Inosine,Phosphorylase, Nicotinamide Riboside,Phosphorylase, Purine-Nucleoside,Phosphorylases, Purine Nucleoside,Purine Nucleoside Phosphorylase,Riboside Phosphorylase, Nicotinamide
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D004791 Enzyme Inhibitors Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D005260 Female Females
D006147 Guanine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
January 1991, Advances in experimental medicine and biology,
E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
August 1993, The Journal of pharmacology and experimental therapeutics,
E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
April 1994, Cancer research,
E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
January 2007, Nucleosides, nucleotides & nucleic acids,
E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
August 1987, Agents and actions,
E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
November 2004, Nihon rinsho. Japanese journal of clinical medicine,
E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
January 2003, Nihon rinsho. Japanese journal of clinical medicine,
E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
December 1996, Nihon rinsho. Japanese journal of clinical medicine,
E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
January 1998, Ryoikibetsu shokogun shirizu,
E Kimble, and J Hadala, and R Ludewig, and P Peters, and G Greenberg, and G Xiao, and W Guida, and L McQuire, and P Simon
January 2003, Nihon rinsho. Japanese journal of clinical medicine,
Copied contents to your clipboard!