-transparent.png){kind=logo}
Trifluopromazine (TFPro) administration to rats (50 mg/kg, ip) 30 min before or 6 or 10 hr after CCl4 treatment (1 ml/kg ip in olive oil) partially prevented necrogenic effects of this compound at 24 hr. TFPro has only minor effects on the covalent binding (CB) of CCl4-reactive metabolites to cellular constituents and even an enhancing action on CCl4-promoted lipid peroxidation (LP). Determination of TFPro levels in liver 1 and 3 hr after administration by gas chromatography/mass spectrometry showed its presence in that tissue at concentrations well above those needed for calmodulin (CaM) inhibitory effects of this drug. TFPro lowered body temperature in CCl4-treated animals during the 24-hr observation period. Protective effects of TFPro at 6 or 10 hr, when most of the CB and all of the LP has already occurred, suggest but do not prove a role for CaM in late stages of CCl4-induced necrogenic effects. Decreases in the body temperature of CCl4-poisoned animals provoked by TFPro might also play a role in the preventive actions of this drug.
E C de Ferreyra, and
A S Bernacchi, and
M F San Martin, and
G D Castro, and
J A Castro
January 1993,
Archives of toxicology,
E C de Ferreyra, and
A S Bernacchi, and
M F San Martin, and
G D Castro, and
J A Castro
May 1984,
Toxicology letters,
E C de Ferreyra, and
A S Bernacchi, and
M F San Martin, and
G D Castro, and
J A Castro
April 1986,
Toxicology and applied pharmacology,
E C de Ferreyra, and
A S Bernacchi, and
M F San Martin, and
G D Castro, and
J A Castro
June 1983,
Research communications in chemical pathology and pharmacology,
E C de Ferreyra, and
A S Bernacchi, and
M F San Martin, and
G D Castro, and
J A Castro
March 1994,
Toxicology letters,
E C de Ferreyra, and
A S Bernacchi, and
M F San Martin, and
G D Castro, and
J A Castro
October 1995,
Experimental and molecular pathology,
E C de Ferreyra, and
A S Bernacchi, and
M F San Martin, and
G D Castro, and
J A Castro
February 1985,
Research communications in chemical pathology and pharmacology,
E C de Ferreyra, and
A S Bernacchi, and
M F San Martin, and
G D Castro, and
J A Castro
December 1986,
Journal of applied toxicology : JAT,
E C de Ferreyra, and
A S Bernacchi, and
M F San Martin, and
G D Castro, and
J A Castro
April 2012,
Pharmacological research,
E C de Ferreyra, and
A S Bernacchi, and
M F San Martin, and
G D Castro, and
J A Castro
January 1980,
Toxicology and applied pharmacology,
