Biomaterial Database

Effect of acute haemodilution on right atrial type-B receptor activity in anaesthetized cats. 1995

S Bhunia, and N Bhattacharya, and M Fahim

Department of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi.

In order to investigate whether the sensitivity of atrial type-B receptors to its natural stimulus is altered during acute haemodilution, experiments were conducted in nine anaesthetized, artificially ventilated and thoracotomized cats. Haemodilution was achieved by replacement of blood by the same volume of dextran (MW 150000). Atrial receptor activity, arterial blood pressure, right atrial pressure and ECG were recorded. Heart rate was calculated from ECG records. Arterial blood hematocrit was measured. Mean arterial blood pressure and heart rate were not altered by haemodilution even at a hematocrit level of 12.17 +/- 0.93 percent. Average activity of type-B atrial receptors, mean right atrial pressure, right atrial peak 'v' pressure, right atrial initial 'v' pressure and right atrial 'v' wave amplitude were changed significantly (r < 0.05) during acute haemodilution when the hematocrit was 12.17 +/- 0.93 percent but the atrial type-B receptor activity per cycle did not show any significant change. Average activity of type-B receptors increased from 8.56 +/- 1.02 spikes/sec to 9.56 +/- 1.11 spikes/sec. Mean right atrial pressure, right atrial 'v' wave amplitude, right atrial peak 'v' pressure increased significantly (P < 0.05) from respective control values. Right atrial initial 'v' wave pressure decreased significantly. Heart rate changed from 168.11 +/- 5.42 beats/min to 170.89 +/- 5.65 beats/min. Mean arterial pressure changed from 134.33 +/- 0.89 mmHg to 135.67 +/- 1.46 mmHg.(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011311	Pressoreceptors	Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.	Baroreceptors,Receptors, Stretch, Arterial,Receptors, Stretch, Vascular,Stretch Receptors, Arterial,Stretch Receptors, Vascular,Arterial Stretch Receptor,Arterial Stretch Receptors,Baroreceptor,Pressoreceptor,Receptor, Arterial Stretch,Receptor, Vascular Stretch,Receptors, Arterial Stretch,Receptors, Vascular Stretch,Stretch Receptor, Arterial,Stretch Receptor, Vascular,Vascular Stretch Receptor,Vascular Stretch Receptors
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D005260	Female		Females
D006321	Heart	The hollow, muscular organ that maintains the circulation of the blood.	Hearts
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006400	Hematocrit	The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.	Erythrocyte Volume, Packed,Packed Red-Cell Volume,Erythrocyte Volumes, Packed,Hematocrits,Packed Erythrocyte Volume,Packed Erythrocyte Volumes,Packed Red Cell Volume,Packed Red-Cell Volumes,Red-Cell Volume, Packed,Red-Cell Volumes, Packed,Volume, Packed Erythrocyte,Volume, Packed Red-Cell,Volumes, Packed Erythrocyte,Volumes, Packed Red-Cell
D006438	Hemodilution	Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.	Hemodilutions
D000758	Anesthesia	A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.