BIOMAT Database Logo BIOMAT Database Logo

Loss of heterozygosity on chromosome 9 in human breast cancer: association with clinical variables and genetic changes at other chromosome regions. 1995

G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
Department of Pathology, University and National Hospital of Iceland, Reykjavik, Iceland.

Primary breast tumors were tested for loss of heterozygosity (LOH), on chromosome 9p with microsatellite markers restricted to a 28 cM region including the MTS1 gene. LOH was found with at least 1 marker in 38% of the 201 cases analyzed. A high frequency of deletions was detected at the 9p23-p21 region, indicating a tumor suppressor gene(s) important for breast cancer tumorigenesis. Tumors with and without LOH on 9p were compared with respect to clinico-pathological factors using chi 2 analysis. Tumors with 9p LOH were significantly associated with high S-phase status and aneuploidy, but not with type, node status, estrogen and progesterone receptor content or age of the patients at diagnosis. Survival analysis showed that LOH at 9p did not significantly affect the survival rate of breast cancer patients. Our results indicate that the aberrations on 9p detected in this study are not of independent prognostic value. A significant association was found between LOH at 9p and LOH at chromosomal arms 3p and 6q, which is an additional contribution toward understanding the genetic events in breast tumor pathogenesis.

UI MeSH Term Description Entries
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002893 Chromosomes, Human, Pair 3 A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification. Chromosome 3
D002896 Chromosomes, Human, Pair 6 A specific pair GROUP C CHROMSOMES of the human chromosome classification. Chromosome 6
D002899 Chromosomes, Human, Pair 9 A specific pair of GROUP C CHROMSOMES of the human chromosome classification. Chromosome 9
D005260 Female Females
D006579 Heterozygote An individual having different alleles at one or more loci regarding a specific character. Carriers, Genetic,Genetic Carriers,Carrier, Genetic,Genetic Carrier,Heterozygotes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000483 Alleles Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product. Allelomorphs,Allele,Allelomorph
D017353 Gene Deletion A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus. Deletion, Gene,Deletions, Gene,Gene Deletions

Related Publications

G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations.
September 1995, British journal of cancer,
G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
Loss of heterozygosity at pseudoautosomal regions in human breast cancer and association with negative hormonal phenotype.
June 2002, Cancer genetics and cytogenetics,
G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
Loss of heterozygosity on chromosome 1q in human breast cancer.
September 1989, Proceedings of the National Academy of Sciences of the United States of America,
G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
Loss of heterozygosity on the X chromosome in human breast cancer.
August 1995, Genes, chromosomes & cancer,
G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
Loss of heterozygosity at BRCA1, TP53, nm-23 and other loci on chromosome 17q in human breast carcinoma.
March 2004, Journal of the Egyptian National Cancer Institute,
G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
Loss of heterozygosity on chromosome 7q31 in breast cancer.
May 1993, Lancet (London, England),
G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
High rates of loss of heterozygosity on chromosome 19p13 in human breast cancer.
February 2001, British journal of cancer,
G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
Loss of heterozygosity, chromosome 7q, and breast cancer.
June 1992, Lancet (London, England),
G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
Loss of heterozygosity on chromosome 11 q in breast cancer.
May 1995, Journal of clinical pathology,
G Eiriksdottir, and A Sigurdsson, and J G Jonasson, and B A Agnarsson, and H Sigurdsson, and J Gudmundsson, and J T Bergthorsson, and R B Barkardottir, and V Egilsson, and S Ingvarsson
Loss of heterozygosity on chromosome 10q in glioblastomas, and its association with other genetic alterations and survival in Indian patients.
January 2011, Neurology India,
Copied contents to your clipboard!