-transparent.png){kind=logo}
The aim of this study was to evaluate the role of human herpesvirus-6 (HHV-6) in the development of primary Sjögren's syndrome (PSS). Serum HHV-6 antibody levels, as measured by immunofluorescence assay (IFA) and the prevalence of HHV-6 DNA in peripheral blood mononuclear cells (PBMCs) determined by polymerase chain reaction (PCR), were studied in 49 PSS patients and 50 control subjects, all in-patients in the University Hospital Internal Medicine ward, Limoges, France. In addition, portions of labial salivary gland were obtained from 34 patients and 15 controls, the presence of viral DNA being detected by the same PCR technique. The results were then compared with clinical observations of systemic disease manifestations in patients and a histological study of salivary gland involvement. No significant difference in HHV-6 seroprevalence was found between control subjects (50.0%) and patients (63.3%) nor was there any statistically significant difference between patient and control groups for total viral DNA in PBMCs (22.4%, 12.0%) and salivary glands (8.8%, 6.6%). Analysis of clinical and histological data revealed no detectable correlation between disease severity and viral involvement. Tests for HHV-6A and HHV-6B proved positive in patient and control groups, HHV-6B being the most frequently encountered type in both groups. In conclusion, the results of this large-scale trial does not confirm the suspected direct role of HHV-6 in the etiology of PSS.
S Ranger-Rogez, and
E Vidal, and
F Labrousse, and
A Riché, and
J Vidal, and
M Collineau, and
F Liozon, and
F Denis
November 1990,
Arthritis and rheumatism,
S Ranger-Rogez, and
E Vidal, and
F Labrousse, and
A Riché, and
J Vidal, and
M Collineau, and
F Liozon, and
F Denis
March 2008,
Expert review of clinical pharmacology,
S Ranger-Rogez, and
E Vidal, and
F Labrousse, and
A Riché, and
J Vidal, and
M Collineau, and
F Liozon, and
F Denis
September 1999,
The Journal of rheumatology,
S Ranger-Rogez, and
E Vidal, and
F Labrousse, and
A Riché, and
J Vidal, and
M Collineau, and
F Liozon, and
F Denis
January 2003,
Annals of the rheumatic diseases,
S Ranger-Rogez, and
E Vidal, and
F Labrousse, and
A Riché, and
J Vidal, and
M Collineau, and
F Liozon, and
F Denis
July 2018,
International journal of rheumatic diseases,
S Ranger-Rogez, and
E Vidal, and
F Labrousse, and
A Riché, and
J Vidal, and
M Collineau, and
F Liozon, and
F Denis
July 2012,
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation,
S Ranger-Rogez, and
E Vidal, and
F Labrousse, and
A Riché, and
J Vidal, and
M Collineau, and
F Liozon, and
F Denis
January 2019,
Acta reumatologica portuguesa,
S Ranger-Rogez, and
E Vidal, and
F Labrousse, and
A Riché, and
J Vidal, and
M Collineau, and
F Liozon, and
F Denis
June 1995,
Journal of clinical microbiology,
S Ranger-Rogez, and
E Vidal, and
F Labrousse, and
A Riché, and
J Vidal, and
M Collineau, and
F Liozon, and
F Denis
February 1982,
American journal of diseases of children (1960),
S Ranger-Rogez, and
E Vidal, and
F Labrousse, and
A Riché, and
J Vidal, and
M Collineau, and
F Liozon, and
F Denis
January 2018,
Indian journal of pathology & microbiology,
