Structural variation of the pseudoautosomal region between and within inbred mouse strains. 1996

D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.

The pseudoautosomal region (PAR) is a segment of shared homology between the sex chromosomes. Here we report additional probes for this region of the mouse genome. Genetic and fluorescence in situ hybridization analyses indicate that one probe, PAR-4, hybridizes to the pseudoautosomal telomere and a minor locus at the telomere of chromosome 9 and that a PCR assay based on the PAR-4 sequence amplifies only the pseudoautosomal locus (DXYHgu1). The region detected by PAR-4 is structurally unstable; it shows polymorphism both between mouse strains and between animals of the same inbred strain, which implies an unusually high mutation rate. Variation occurs in the region adjacent to a (TTAGGG)n array. Two pseudoautosomal probes can also hybridize to the distal telomeres of chromosomes 9 and 13, and all three telomeres contain DXYMov15. The similarity between these telomeres may reflect ancestral telomere-telomere exchange.

UI MeSH Term Description Entries
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D012150 Polymorphism, Restriction Fragment Length Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment. RFLP,Restriction Fragment Length Polymorphism,RFLPs,Restriction Fragment Length Polymorphisms
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D003001 Cloning, Molecular The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells. Molecular Cloning
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D014960 X Chromosome The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species. Chromosome, X,Chromosomes, X,X Chromosomes
D014998 Y Chromosome The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained. Chromosome, Y,Chromosomes, Y,Y Chromosomes
D016615 Telomere A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs. Telomeres

Related Publications

D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
February 2001, Trends in neurosciences,
D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
March 2023, BMC genomics,
D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
August 2004, BMC genomics,
D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
July 1986, The American journal of anatomy,
D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
April 1954, Nature,
D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
October 1983, Genetical research,
D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
July 1999, Brain research,
D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
June 2008, Genome research,
D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
July 2004, Genome research,
D Kipling, and H E Wilson, and E J Thomson, and M Lee, and J Perry, and S Palmer, and A Ashworth, and H J Cooke
August 2015, Mammalian genome : official journal of the International Mammalian Genome Society,
Copied contents to your clipboard!