-transparent.png){kind=logo}
beta-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by uncoupling the signal transduction process. Resensitization of GPCR responsiveness involves agonist-mediated receptor sequestration. Overexpression of beta-arrestins in human embryonic kidney cells rescued the sequestration of beta 2-adrenergic receptor (beta 2AR) mutants defective in their ability to sequester, an effect enhanced by simultaneous overexpression of beta-adrenergic receptor kinase 1. Wild-type beta 2AR sequestration was inhibited by the overexpression of two beta-arrestin mutants. These findings suggest that beta-arrestins play an integral role in GPCR internalization and thus serve a dual role in the regulation of GPCR function.
S S Ferguson, and
W E Downey, and
A M Colapietro, and
L S Barak, and
L Ménard, and
M G Caron
August 1996,
The Journal of biological chemistry,
S S Ferguson, and
W E Downey, and
A M Colapietro, and
L S Barak, and
L Ménard, and
M G Caron
March 2002,
The Journal of biological chemistry,
S S Ferguson, and
W E Downey, and
A M Colapietro, and
L S Barak, and
L Ménard, and
M G Caron
April 2003,
The Journal of biological chemistry,
S S Ferguson, and
W E Downey, and
A M Colapietro, and
L S Barak, and
L Ménard, and
M G Caron
September 2004,
Molecular pharmacology,
S S Ferguson, and
W E Downey, and
A M Colapietro, and
L S Barak, and
L Ménard, and
M G Caron
March 2006,
The Journal of biological chemistry,
S S Ferguson, and
W E Downey, and
A M Colapietro, and
L S Barak, and
L Ménard, and
M G Caron
November 2001,
The Journal of biological chemistry,
S S Ferguson, and
W E Downey, and
A M Colapietro, and
L S Barak, and
L Ménard, and
M G Caron
January 1999,
Journal of receptor and signal transduction research,
S S Ferguson, and
W E Downey, and
A M Colapietro, and
L S Barak, and
L Ménard, and
M G Caron
July 1998,
Trends in cardiovascular medicine,
S S Ferguson, and
W E Downey, and
A M Colapietro, and
L S Barak, and
L Ménard, and
M G Caron
January 2022,
Biological chemistry,
S S Ferguson, and
W E Downey, and
A M Colapietro, and
L S Barak, and
L Ménard, and
M G Caron
November 2005,
The Journal of biological chemistry,
