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In order to estimate the potential advantages of new chelating agents which can enhance copper excretion in the chronic copper intoxication arising in Wilson's disease, the relative ability of none chelating agents to induce the urinary excretion of copper was compared with that of D-penicillamine (DPA) and triethylenetetramine.2HCl (TRIEN), all given ip at 1 mmol/kg to male Sprague-Dawley rats. The compounds examined were as follows: tris(2-aminoethyl)-amine.3HCl (TREN), tetraethylenepentamine.5HCl (TETREN), pentaethylenehexamine.6HCl (PENTEN), 1,4,7,11-tetraazaundecane.4HCl (TAUD), 1,5,8,12-tetraazadodecane.4HCl (TADD), 1-N-benzyltriethylenetetramine.4HCl (BzTT), 4,7,10,13-tetraazatridecanoic acid.2H2SO4 (TTPA), 1,10-bis(2-pyridylmethyl)-1,4,7,10-tetraazadecane.4HCl (BPTETA), and N,N-bis(2-pyridylmethyl)-4-(aminomethyl)benzoic acid (4ABA). Of these, BzTT, TTPA, and 4ABA are new chelating agents not previously reported. The factors by which these chelating agents enhanced copper excretion over control (untreated) levels were as follows: DPA, 7.2; TREN, 1.6; TRIEN, 4.0; TETREN, 10.1; PENTEN, 7.8; TAUD, 7.8; TADD, 2.6; TTPA, 5.6; BzTT, 1.8; and 4ABA, 5.5. The results indicate that it may well be possible to develop additional chelating agents which are equal or superior to those now used in the treatment of Wilson's disease, as well as structural types whose immunological properties may be significantly different from DPA or TRIEN, the compounds currently used in the clinic for this disorder.
M M Jones, and
P K Singh, and
L J Zimmerman, and
M Gomez, and
M L Albina, and
J L Domingo
September 1967,
The British veterinary journal,
M M Jones, and
P K Singh, and
L J Zimmerman, and
M Gomez, and
M L Albina, and
J L Domingo
January 1991,
Fundamental & clinical pharmacology,
M M Jones, and
P K Singh, and
L J Zimmerman, and
M Gomez, and
M L Albina, and
J L Domingo
January 1987,
Journal of hygiene, epidemiology, microbiology, and immunology,
M M Jones, and
P K Singh, and
L J Zimmerman, and
M Gomez, and
M L Albina, and
J L Domingo
September 1979,
Toxicology and applied pharmacology,
M M Jones, and
P K Singh, and
L J Zimmerman, and
M Gomez, and
M L Albina, and
J L Domingo
October 1977,
Clinical science and molecular medicine,
M M Jones, and
P K Singh, and
L J Zimmerman, and
M Gomez, and
M L Albina, and
J L Domingo
January 1967,
Annales medicinae experimentalis et biologiae Fenniae,
M M Jones, and
P K Singh, and
L J Zimmerman, and
M Gomez, and
M L Albina, and
J L Domingo
November 1986,
Toxicology letters,
M M Jones, and
P K Singh, and
L J Zimmerman, and
M Gomez, and
M L Albina, and
J L Domingo
November 1965,
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
M M Jones, and
P K Singh, and
L J Zimmerman, and
M Gomez, and
M L Albina, and
J L Domingo
February 1971,
Toxicology and applied pharmacology,
M M Jones, and
P K Singh, and
L J Zimmerman, and
M Gomez, and
M L Albina, and
J L Domingo
November 2003,
Huan jing ke xue= Huanjing kexue,
