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In many degenerative and metabolic muscle diseases cells die without a marked inflammatory response. A potential mechanism how this could be accomplished is apoptotic cell death. Since there are no data available about apoptosis in cells of myogenic origin, we examined rat skeletal myoblasts for their potential to undergo apoptosis when exposed to reactive oxygen intermediates and nitric oxide. We observed morphologic changes typical for apoptotic cell death, and DNA fragmentation was confirmed by gel electrophoresis and molecular labeling assays. With these methods we could show that both reactive oxygen intermediates and nitric oxide can induce apoptosis in myoblasts in a dose-dependent manner. These results are discussed with regard to possible implications on the pathophysiology of various muscle diseases.
M Stangel, and
U K Zettl, and
E Mix, and
J Zielasek, and
K V Toyka, and
H P Hartung, and
R Gold
November 2005,
Nitric oxide : biology and chemistry,
M Stangel, and
U K Zettl, and
E Mix, and
J Zielasek, and
K V Toyka, and
H P Hartung, and
R Gold
May 2003,
Kidney international. Supplement,
M Stangel, and
U K Zettl, and
E Mix, and
J Zielasek, and
K V Toyka, and
H P Hartung, and
R Gold
May 1998,
Cell and tissue research,
M Stangel, and
U K Zettl, and
E Mix, and
J Zielasek, and
K V Toyka, and
H P Hartung, and
R Gold
June 2014,
American journal of physiology. Cell physiology,
M Stangel, and
U K Zettl, and
E Mix, and
J Zielasek, and
K V Toyka, and
H P Hartung, and
R Gold
January 2001,
Biological signals and receptors,
M Stangel, and
U K Zettl, and
E Mix, and
J Zielasek, and
K V Toyka, and
H P Hartung, and
R Gold
May 2006,
BMC biochemistry,
M Stangel, and
U K Zettl, and
E Mix, and
J Zielasek, and
K V Toyka, and
H P Hartung, and
R Gold
November 2014,
Molecular biology reports,
M Stangel, and
U K Zettl, and
E Mix, and
J Zielasek, and
K V Toyka, and
H P Hartung, and
R Gold
September 2005,
The Journal of nutrition,
M Stangel, and
U K Zettl, and
E Mix, and
J Zielasek, and
K V Toyka, and
H P Hartung, and
R Gold
September 1999,
Mechanisms of ageing and development,
M Stangel, and
U K Zettl, and
E Mix, and
J Zielasek, and
K V Toyka, and
H P Hartung, and
R Gold
May 1996,
The American journal of physiology,
