BIOMAT Database Logo BIOMAT Database Logo

Penetration of cefazolin, cephaloridine, and cefamandole into interstitial fluid in rabbits. 1977

C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon

We compared the penetration of three cephalosporins into interstitial fluid. Interstitial fluid was obtained in rabbits from Silastic tissue cages. Cefazolin, cephaloridine, and cefamandole were administered by the intramuscular route (30 mg/kg per injection). Peak blood levels and interstitial concentrations were studied after a single injection. Interstitial levels were also compared in a three-injection study (one injection every 12 h) and in a cumulative effect study (six injections), in which the interval between injections was established for each drug on the basis of its common therapeutic use. After a single injection, cephaloridine activity was detected more rapidly and attained higher levels than the other two drugs within the first 4 h. However, 2 h after the third injection, cefazolin levels in tissue fluid were higher than with cephaloridine. Cefamandole consistently gave the lowest interstitial levels. With all three drugs, detectable concentrations were present in interstitial fluid at a time when no detectable antibiotic was found in serum. In the six-injection study, the interstitial levels obtained with cefazolin were significantly higher than those observed with the other drugs. Our data suggest that cefazolin is a drug of choice due to its high extravascular levels.

UI MeSH Term Description Entries
D008333 Mandelic Acids Analogs or derivatives of mandelic acid (alpha-hydroxybenzeneacetic acid). Acids, Mandelic
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D001826 Body Fluids Liquid components of living organisms. Body Fluid,Fluid, Body,Fluids, Body
D002437 Cefazolin A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. Cephazolin,Ancef,Cefamedin,Cefamezine,Cefazolin Sodium,Cephamezine,Cephazolin Sodium,Gramaxin,Kefzol,Sodium Cephazolin,Totacef,Cephazolin, Sodium,Sodium, Cefazolin,Sodium, Cephazolin
D002509 Cephaloridine A cephalosporin antibiotic. Cefaloridine,Cephalomycine,Cephaloridin,Ceporin
D002511 Cephalosporins A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid. Antibiotics, Cephalosporin,Cephalosporanic Acid,Cephalosporin,Cephalosporin Antibiotic,Cephalosporanic Acids,Acid, Cephalosporanic,Acids, Cephalosporanic,Antibiotic, Cephalosporin,Cephalosporin Antibiotics
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001692 Biological Transport The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments. Transport, Biological,Biologic Transport,Transport, Biologic

Related Publications

C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon
Penetration of cefpiramide and cefazolin into peritoneal capsular fluid in rabbits.
January 1988, Antimicrobial agents and chemotherapy,
C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon
Penetration of cefamandole into spinal fluid.
June 1977, Antimicrobial agents and chemotherapy,
C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon
Penetration of cephaloridine into cerebrospinal fluid.
December 1971, The American journal of the medical sciences,
C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon
Penetration of cefazolin into pleural fluid.
June 1977, Antimicrobial agents and chemotherapy,
C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon
Penetration of cephaloridine into the subretinal fluid.
June 1973, The British journal of ophthalmology,
C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon
Protein binding and concentrations of cephaloridine and cefazolin in serum and interstitial fluid of dogs.
June 1976, The Journal of infectious diseases,
C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon
Cephalothin and cefamandole penetration into bone, synovial fluid, and wound drainage fluid.
September 1980, The Journal of bone and joint surgery. American volume,
C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon
Pharmacokinetics and penetration characteristics of cefazolin into human spinal fluid.
January 1976, Current therapeutic research, clinical and experimental,
C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon
Levels of carbenicillin, ticarcillin, cephalothin, cefazolin, cefamandole, gentamicin, tobramycin, and amikacin in human serum and interstitial fluid.
April 1977, Antimicrobial agents and chemotherapy,
C Carbon, and A Contrepois, and N Brion, and S Lamotte-Barrillon
[Investigations on the penetration of cefamandole into spinal fluid (author's transl)].
January 1978, Infection,
Copied contents to your clipboard!