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Five young women were treated by splenectomy for epidermoid cysts of the spleen. They all had vague abdominal symptoms, and had a mass palpable in the left upper quadrant of the abdomen. The hematologic indices were unremarkable. The diagnosis was suggested by routine radiologic examinations (including chest roentgenogram, upper gastrointestinal x-ray series, barium enema, and excretory urogram). It was confirmed in one patient by gray-scale ultrasonography, and in another by selective splenic arteriography. Of the true cysts of the spleen, the epidermoid cyst is the rarest, representing 10% of the benign, nonparaslitic cysts. The symptoms are completely relieved by splenectomy, and this remains the treatment of choice.
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