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An increased risk for regional enteritis patients of small bowel adenocarcinoma to develop has been suspected but unproved. We have analyzed 49 cases reported since 1957 and two additional ones of our own. These have been compared with a current group of small bowel adenocarcinomas not associated with regional enteritis. The Crohn-associated cancers differed from adenocarcinomas not associated with Crohn disease in that (1) mean age at cancer discovery was less (46 vs 64 years), (2) more cancers arose in the ileum (76% vs 27%), (3) diagnosis and cure were less successful, and (4) they occurred more frequently. The 32 cases reported in the past five years were compared with the expected 0.1 to 5 cases. Regional enteritis patients were found to have an increased risk for the development not only of small bowel adenocarcinoma, but one that is more occult and lethal than that in individuals wihtout Crohn disease.
J P Hoffman, and
D A Taft, and
R F Wheelis, and
J H Walker
January 1964,
Journal of the Mount Sinai Hospital, New York,
J P Hoffman, and
D A Taft, and
R F Wheelis, and
J H Walker
February 1985,
Cancer,
J P Hoffman, and
D A Taft, and
R F Wheelis, and
J H Walker
February 1967,
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J P Hoffman, and
D A Taft, and
R F Wheelis, and
J H Walker
August 1972,
Deutsche medizinische Wochenschrift (1946),
J P Hoffman, and
D A Taft, and
R F Wheelis, and
J H Walker
December 1973,
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J P Hoffman, and
D A Taft, and
R F Wheelis, and
J H Walker
August 1972,
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J P Hoffman, and
D A Taft, and
R F Wheelis, and
J H Walker
April 1969,
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J P Hoffman, and
D A Taft, and
R F Wheelis, and
J H Walker
October 1970,
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J P Hoffman, and
D A Taft, and
R F Wheelis, and
J H Walker
February 1972,
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J P Hoffman, and
D A Taft, and
R F Wheelis, and
J H Walker
December 1980,
Gut,
