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The effects of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen were studied in groups of healthy adult males, females and oral contraceptive steroid (OCS) using females. The values of AUC, CLpo, t1/2 and Vss, app did not differ significantly between the groups. Similarly, the percentage unbound of (R)-ibuprofen in pooled plasma from the three groups was not statistically different. Since chiral inversion is the major determinant of (R)-ibuprofen clearance in humans, it may be inferred from these data that gender and OCS have little or no effect on conversion of (R)-ibuprofen to the pharmacologically active S-enantiomer. Moreover, it is unlikely that hormonal factors influence the activity of the human hepatic long-chain fatty-acid:CoA ligase, the enzyme mediating the rate limiting step of (R)-ibuprofen inversion.
K M Knights, and
C F McLean, and
A L Tonkin, and
J O Miners
January 1986,
Contraception,
K M Knights, and
C F McLean, and
A L Tonkin, and
J O Miners
November 1996,
British journal of clinical pharmacology,
K M Knights, and
C F McLean, and
A L Tonkin, and
J O Miners
July 1990,
British journal of clinical pharmacology,
K M Knights, and
C F McLean, and
A L Tonkin, and
J O Miners
August 1989,
British journal of clinical pharmacology,
K M Knights, and
C F McLean, and
A L Tonkin, and
J O Miners
February 1991,
British journal of clinical pharmacology,
K M Knights, and
C F McLean, and
A L Tonkin, and
J O Miners
January 1983,
Clinical pharmacokinetics,
K M Knights, and
C F McLean, and
A L Tonkin, and
J O Miners
January 1982,
Carcinogenesis,
K M Knights, and
C F McLean, and
A L Tonkin, and
J O Miners
December 2011,
Journal of clinical pharmacology,
K M Knights, and
C F McLean, and
A L Tonkin, and
J O Miners
January 1998,
European journal of clinical pharmacology,
K M Knights, and
C F McLean, and
A L Tonkin, and
J O Miners
April 1993,
Clinical pharmacology and therapeutics,
