Not only is MR imaging maximally sensitive to the presence of musculoskeletal soft-tissue lesions, but also it provides exquisite definition of their features. Categorization of the many distinct attributes of the lesions is the key to differentiation of benign from malignant processes. Combining the observations concerning the architectural details with the location and pattern of growth, and finally with the specific MR signal characteristics and contrast enhancement patterns, will produce the most limited differential diagnosis possible. Although there are few, if any, pathognomonic findings for malignant or benign lesions in diagnostic imaging, a high degree of confidence or statistical likelihood can be achieved in many instances using MR imaging.