Cancer is a leading cause of morbidity and mortality in the United States, affecting one of four Americans. Many nurses without specialized oncology preparation will provide counsel and care for people at risk for or with cancer. In recognition of the cancer-related educational needs for all nurses in the wide variety of health care settings, the American Cancer Society Professors of Oncology Nursing provide a curriculum guide for core cancer nursing content in undergraduate education for baccalaureate students. It is intended to assist educators to define expectations for clinical competencies in cancer care for preparing graduates at the baccalaureate level. A variety of educational strategies and resources for the educator are suggested to facilitate integration of cancer content within existing programs.