-transparent.png){kind=logo}
The effects of diazepam on morphine-induced place preference were examined in mice. Pretreatment with diazepam (2 mg/kg i.p.) 30 min prior to morphine injection significantly abolished the morphine (5 mg/kg s.c.)-induced place preference, and this effect of diazepam was antagonized by pretreatment with flumazenil. In addition, pretreatment with diazepam prevented the morphine (5 mg/kg s.c.)-induced increase in dopamine turnover in the limbic forebrain. These results suggest that pretreatment with diazepam may suppress the rewarding effects of morphine.
Related Publications
T Suzuki, and
M Tsuda, and
M Funada, and
M Misawa
September 1994,
Japanese journal of pharmacology,
T Suzuki, and
M Tsuda, and
M Funada, and
M Misawa
October 2006,
Pharmacology, biochemistry, and behavior,
T Suzuki, and
M Tsuda, and
M Funada, and
M Misawa
November 2007,
Neuroscience,
T Suzuki, and
M Tsuda, and
M Funada, and
M Misawa
July 2000,
Psychopharmacology,
T Suzuki, and
M Tsuda, and
M Funada, and
M Misawa
February 1998,
Neuroscience letters,
T Suzuki, and
M Tsuda, and
M Funada, and
M Misawa
January 2003,
Neural plasticity,
T Suzuki, and
M Tsuda, and
M Funada, and
M Misawa
June 2004,
Neuroreport,
T Suzuki, and
M Tsuda, and
M Funada, and
M Misawa
October 1997,
European journal of pharmacology,
T Suzuki, and
M Tsuda, and
M Funada, and
M Misawa
June 2001,
Behavioural brain research,
T Suzuki, and
M Tsuda, and
M Funada, and
M Misawa
July 2005,
Behavioural pharmacology,
