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The study of bone marrow hemopoiesis, the count of hemopoietic precursor cells, bone marrow structural and functional organization, the level of humoral stimulators and secretion by hemopoiesis-inducing microenvironment (HIM) cells following a single injection of 5-fluorouracil, cyclophosphamide or adriamycin has found out that cytostatic-related changes in hemopoiesis recovery depend primarily on relationships between proliferation and differentiation of hemopoietic cells. These relationships are dictated by the state of HIM cells. Enhanced functional activity of HIM elements in response to hemopoietic tissue damage caused by adriamycin or cyclophosphamide promotes rapid hemopoiesis regeneration. At the same time, 5-fluorouracil gave rise to prolonged bone marrow hypoplasia, severe disorder of microenvironment cell function.
A M Dygaĭ, and
V V Zhdanov, and
I A Khlusov, and
P A Liubavina, and
E D Gol'dberg
January 1991,
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A M Dygaĭ, and
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E D Gol'dberg
January 1990,
Vestnik Akademii meditsinskikh nauk SSSR,
A M Dygaĭ, and
V V Zhdanov, and
I A Khlusov, and
P A Liubavina, and
E D Gol'dberg
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Annals of the New York Academy of Sciences,
A M Dygaĭ, and
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I A Khlusov, and
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E D Gol'dberg
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A M Dygaĭ, and
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P A Liubavina, and
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A M Dygaĭ, and
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E D Gol'dberg
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Deutsche medizinische Wochenschrift (1946),
A M Dygaĭ, and
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I A Khlusov, and
P A Liubavina, and
E D Gol'dberg
August 1964,
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A M Dygaĭ, and
V V Zhdanov, and
I A Khlusov, and
P A Liubavina, and
E D Gol'dberg
January 1992,
Biulleten' eksperimental'noi biologii i meditsiny,
A M Dygaĭ, and
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I A Khlusov, and
P A Liubavina, and
E D Gol'dberg
January 1995,
Die Pharmazie,
A M Dygaĭ, and
V V Zhdanov, and
I A Khlusov, and
P A Liubavina, and
E D Gol'dberg
January 1991,
Neoplasma,
