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OBJECTIVE This preliminary study was undertaken to determine whether the valence state of dietary iron affects signs associated with copper deficiency in rats fed fructose. METHODS Rats were fed either copper-deficient or adequate diets containing 62% fructose as the sole dietary carbohydrate for 5 weeks. The mineral mixture contained equal concentration of either ferric or ferrous iron. RESULTS Copper deficiency resulted in growth retardation, anemia, heart hypertrophy but pancreatic atrophy. The consumption of ferrous iron resulted in increased hematocrit and pancreas size. The combination of ferrous iron with copper deficiency reduced heart size. CONCLUSIONS Copper deficiency had a major impact on each parameter measured. Although the valence state of iron did not protect the rats against the pathological consequence of copper deficiency it did have some positive effects. It may be that ferrous iron is a more available form than ferric iron.
M Fields, and
C G Lewis, and
M D Lure, and
W A Burns
June 2012,
American journal of physiology. Lung cellular and molecular physiology,
M Fields, and
C G Lewis, and
M D Lure, and
W A Burns
March 1968,
Canadian journal of biochemistry,
M Fields, and
C G Lewis, and
M D Lure, and
W A Burns
July 1993,
The British journal of nutrition,
M Fields, and
C G Lewis, and
M D Lure, and
W A Burns
January 1974,
Nutrition and metabolism,
M Fields, and
C G Lewis, and
M D Lure, and
W A Burns
July 1986,
The Journal of nutrition,
M Fields, and
C G Lewis, and
M D Lure, and
W A Burns
July 2001,
Nutrition research (New York, N.Y.),
M Fields, and
C G Lewis, and
M D Lure, and
W A Burns
October 1992,
Biological trace element research,
M Fields, and
C G Lewis, and
M D Lure, and
W A Burns
January 1991,
Magnesium research,
M Fields, and
C G Lewis, and
M D Lure, and
W A Burns
October 1983,
Lipids,
M Fields, and
C G Lewis, and
M D Lure, and
W A Burns
August 1983,
Lipids,
