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One hundred twenty-six isolates of Salmonella typhimurium from various clinical sources were tested for enterotoxin production and characterization of plasmid profile. Cell-free culture supernates and polymyxin B extracts of all the strains were assayed by rabbit ileal loop and skin permeability tests. Enterotoxic activity was detected in culture supernates of 32 strains. Twenty-one strains by both rabbit ileal loop and skin permeability tests, nine strains by skin permeability test, and two strains by rabbit ileal loop test were positive. Live culture of three enterotoxic strains, positive in culture supernates produced ileal secretion. Polymyxin B extracts from 6 hours and 18 hours broth cultures of all the strains were devoid of enterotoxicity. Ileal mucosa exposed to culture supernate of enterotoxigenic strains showed swollen and blunted villi with submucosal oedema while those exposed to polymyxin B extracts showed shortening of villi and sloughing of epithelial lining. Plasmid profiles of enterotoxigenic strains were heterogenous and grouped into 20 different profiles. No correlation could be established between plasmid profile, R-pattern, and enterotoxin production.
V P Mohan, and
K B Sharma, and
D S Agarwal, and
G Purnima, and
P K Pillai
November 2000,
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
V P Mohan, and
K B Sharma, and
D S Agarwal, and
G Purnima, and
P K Pillai
February 1986,
Journal of medical microbiology,
V P Mohan, and
K B Sharma, and
D S Agarwal, and
G Purnima, and
P K Pillai
December 1992,
Avian pathology : journal of the W.V.P.A,
V P Mohan, and
K B Sharma, and
D S Agarwal, and
G Purnima, and
P K Pillai
February 1994,
Microbial pathogenesis,
V P Mohan, and
K B Sharma, and
D S Agarwal, and
G Purnima, and
P K Pillai
March 2001,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
V P Mohan, and
K B Sharma, and
D S Agarwal, and
G Purnima, and
P K Pillai
January 1997,
Journal of applied microbiology,
V P Mohan, and
K B Sharma, and
D S Agarwal, and
G Purnima, and
P K Pillai
May 1991,
The Indian journal of medical research,
V P Mohan, and
K B Sharma, and
D S Agarwal, and
G Purnima, and
P K Pillai
January 1991,
Indian journal of pathology & microbiology,
V P Mohan, and
K B Sharma, and
D S Agarwal, and
G Purnima, and
P K Pillai
July 1991,
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
V P Mohan, and
K B Sharma, and
D S Agarwal, and
G Purnima, and
P K Pillai
April 1972,
Infection and immunity,
