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Rabbit anti-rat xenoantisera were raised by intravenous injection of splenic lymphocytes. After absorption with the appropriate rat red blood cells for removal of 'species-specific' antibodies, many agglutinating specificities remained which were quite similar to the corresponding alloantisera with the exception of the Ag-B5 haplotype. In attempts to produce specific Ag-B xeno-antisera, two groups of histocompatibility antigens were discovered: one consisting of Ag-B1, Ag-B3, Ag-B4, Ag-B7 and Ag-B8 to which specific Ag-B antisera could be produced, and another comprised of Ag-B2, Ag-B5 and Ag-B6 to which specific Ag-B antisera could not be made by any of several methods. Xenoantisera produced by a rapid hyperimmunization technique and all alloantisera tested were cytotoxic, whereas no cytotoxic antibodies could be detected in the xenoantisera produced by a longer course of immunization.
P A Edwards, and
H W Kunz, and
T J Gill
March 1971,
Transplantation proceedings,
P A Edwards, and
H W Kunz, and
T J Gill
February 1971,
Transplantation,
P A Edwards, and
H W Kunz, and
T J Gill
August 1977,
Transplantation,
P A Edwards, and
H W Kunz, and
T J Gill
December 1978,
Transplantation proceedings,
P A Edwards, and
H W Kunz, and
T J Gill
February 1976,
Journal of immunogenetics,
P A Edwards, and
H W Kunz, and
T J Gill
April 1976,
Journal of immunogenetics,
P A Edwards, and
H W Kunz, and
T J Gill
January 1973,
Tissue antigens,
P A Edwards, and
H W Kunz, and
T J Gill
February 1971,
Transplantation,
P A Edwards, and
H W Kunz, and
T J Gill
January 1974,
Transplantation,
P A Edwards, and
H W Kunz, and
T J Gill
March 1969,
Transplantation proceedings,
