Biomaterial Database

Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. 1995

M S Melis

Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras Universidade de São Paulo, Ribeirão Preto, Brazil.

The effects of administration of Stevia rebaudiana extracts for 20, 40 and 60 days on renal function and mean arterial pressure in normal Wistar rats were evaluated. Results showed that the Stevia rebaudiana treated rats group for 20 days did not significantly differ from the control group. Chronic administration of a crude extract for 40 and 60 days induced hypotension, diuresis and natriuresis with glomerular filtration rate (GFR) constant. An increase of the renal plasma flow (RPF) was exclusively observed for the group treated for 60 days. The results suggests that oral administration to rats of an aqueous extract of Stevia dried leaves induce systemic and renal vasodilation, causing hypotension, diuresis and natriuresis.

UI	MeSH Term	Description	Entries
D007022	Hypotension	Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.	Blood Pressure, Low,Hypotension, Vascular,Low Blood Pressure,Vascular Hypotension
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D007677	Kidney Function Tests	Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.	Function Test, Kidney,Function Tests, Kidney,Kidney Function Test,Test, Kidney Function,Tests, Kidney Function
D008297	Male		Males
D009318	Natriuresis	Sodium excretion by URINATION.	Natriureses
D010936	Plant Extracts	Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.	Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D012079	Renal Circulation	The circulation of the BLOOD through the vessels of the KIDNEY.	Kidney Circulation,Renal Blood Flow,Circulation, Kidney,Circulation, Renal,Blood Flow, Renal,Flow, Renal Blood
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004231	Diuresis	An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Diureses
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration