BIOMAT Database Logo BIOMAT Database Logo

Photodynamic laser cyclodestruction with chloroaluminum sulfonated phthalocyanine (CASPc) or Photofrin (PII) vs. Nd:YAG laser cyclodestruction in a pigmented rabbit model. 1995

R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
Department of Ophthalmology, University of California, Irvine 92717, USA.

OBJECTIVE To investigate Photofrin (PII) and CASPc for photodynamic therapy (PDT) of the ciliary body in rabbits. METHODS PII (10 mg/kg) or CASPc (1 mg/kg) was given by ear vein. Pharmacokinetics were studied in frozen sections by fluorescence microscopy (CCD camera based low light detection system with digital image processing) at 1 and 24 h (8 rabbits; 16 eyes). Laser light was delivered (argon pumped dye laser; 630 and 675 nm; 8 rabbits; 16 eyes) by contact fiberoptic. To compensate for iris attenuation, irradiance was 125 mW/cm2 (20, 40, 80, or 160 J/cm2). Controls (4 rabbits; 8 eyes) received laser light without photochemicals (OD) and for comparison, continuous wave Nd:YAG laser by fiberoptic (0.8-1.2J; OS). RESULTS Localization studies showed intravascular distribution with some selective ciliary body distribution at 24 h (PII > CASPc). Rabbits treated with PII or CASPc exhibited variable amounts of gross ciliary body edema, infarction, and necrosis by 24-48 h. This response was not seen in PDT control tissues; damage was seen in the iris and ciliary body, with partial vacuolization of the pigment epithelium. CONCLUSIONS PDT may offer a more selective approach to ciliary body destruction. A small but significant thermal effect was seen during PDT from melanin photon uptake with damage to iris and ciliary body. Thermal damage and potential interaction with ocular visual pigments may limit use of these photochemicals and wavelengths for PDT of the ciliary body.

UI MeSH Term Description Entries
D007211 Indoles Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008856 Microscopy, Fluorescence Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye. Fluorescence Microscopy,Immunofluorescence Microscopy,Microscopy, Immunofluorescence,Fluorescence Microscopies,Immunofluorescence Microscopies,Microscopies, Fluorescence,Microscopies, Immunofluorescence
D009942 Organometallic Compounds A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed) Metallo-Organic Compound,Metallo-Organic Compounds,Metalloorganic Compound,Organometallic Compound,Metalloorganic Compounds,Compound, Metallo-Organic,Compound, Metalloorganic,Compound, Organometallic,Compounds, Metallo-Organic,Compounds, Metalloorganic,Compounds, Organometallic,Metallo Organic Compound,Metallo Organic Compounds
D010778 Photochemotherapy Therapy using oral or topical photosensitizing agents with subsequent exposure to light. Blue Light Photodynamic Therapy,Photodynamic Therapy,Red Light PDT,Red Light Photodynamic Therapy,Therapy, Photodynamic,Light PDT, Red,PDT, Red Light,Photochemotherapies,Photodynamic Therapies,Therapies, Photodynamic
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002924 Ciliary Body A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion. Corpus Ciliare,Corpus Ciliaris,Bodies, Ciliary,Body, Ciliary,Ciliare, Corpus,Ciliares, Corpus,Ciliari, Corpus,Ciliaris, Corpus,Ciliary Bodies,Corpus Ciliares,Corpus Ciliari
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017319 Photosensitizing Agents Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms. Photosensitizer,Photosensitizers,Photosensitizing Agent,Photosensitizing Effect,Photosensitizing Effects,Agent, Photosensitizing,Agents, Photosensitizing,Effect, Photosensitizing,Effects, Photosensitizing
D017323 Dihematoporphyrin Ether The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States. DHP Ether,Porfimer,Dihematoporphyrin Ester,Photofrin,Photofrin II,Porfimer Sodium,Ether, Dihematoporphyrin

Related Publications

R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
Photodynamic therapy with chloroaluminum-sulfonated phthalocyanine.
November 1990, Archives of otolaryngology--head & neck surgery,
R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
Photodynamic therapy with chloroaluminum sulfonated phthalocyanine in the rat window chamber.
October 1990, American journal of surgery,
R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
Photodynamic therapy of experimental subchoroidal melanoma using chloroaluminum sulfonated phthalocyanine.
April 1992, Archives of ophthalmology (Chicago, Ill. : 1960),
R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
Photodynamic therapy for experimental intraocular melanoma using chloroaluminum sulfonated phthalocyanine.
June 1989, Archives of ophthalmology (Chicago, Ill. : 1960),
R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
Effect of aspirin on photodynamic therapy utilizing chloroaluminum sulfonated phthalocyanine (CASP).
January 1992, Lasers in surgery and medicine,
R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
Photothrombosis of retinal and choroidal vessels in rabbit eyes using chloroaluminum sulfonated phthalocyanine and a diode laser.
January 1996, Lasers in surgery and medicine,
R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
Combined photodynamic therapy with chloroaluminum phthalocyanine and doxorubicin nanoemulsions in breast cancer model.
May 2021, Journal of photochemistry and photobiology. B, Biology,
R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
Chloroaluminum sulfonated phthalocyanine partitioning in normal and intimal hyperplastic artery in the rat. Implications for photodynamic therapy.
June 1993, The American journal of pathology,
R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
Initiation of apoptosis versus necrosis by photodynamic therapy with chloroaluminum phthalocyanine.
October 1997, Photochemistry and photobiology,
R A Hill, and T Esterowitz, and J Ryan, and L H Liaw, and J S Nelson, and H Yashiro, and T Krasieva, and M W Berns
In vitro effects of photodynamic therapy induced by chloroaluminum phthalocyanine nanoemulsion.
December 2016, Photodiagnosis and photodynamic therapy,
Copied contents to your clipboard!