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We are currently using caprine arthritis encephalitis virus (CAEV) infection in goats as a model to understand changes in some clinical parameters and host response to infection with human immunodeficiency virus (HIV). The objective of this study was to measure changes in serum antioxidant activities in various age groups of goats infected with CAEV. Serum from CAEV-infected goats had significantly higher catalase activity (105.47 +/- 5.96 kU/l) than serum from healthy control goats (79.92 +/- 17.06 kU/l). Moreover, serum catalase activity increased with increase in the time after infection with CAEV. No change was observed in total superoxide dismutase (SOD) or glutathione peroxidase activity although CuZn SOD levels were elevated in infected goats. There was a positive correlation between serum catalase activity and hydrogen peroxide (H2O2) scavenging activity (r = 0.70, p < 0.05). In order to investigate cell membrane integrity, we determined lactate dehydrogenase (LDH) activity in infected goats. Although there was a transient increase in LDH no correlation was observed between increased serum catalase activity and LDH activity (r = 0.16, p > 0.05). We have earlier observed decreased oxyradical production in CAEV infected goats. This observed increase in serum catalase, a scavenger of endogenous free radicals such as H2O2 may be partly responsible for the observed decrease in oxygen radicals found in vivo.
E G Mdurvwa, and
P O Ogunbiyi, and
P G Reddy, and
H S Gakou, and
S O Sodeke, and
A J Carty
June 1994,
Laboratory investigation; a journal of technical methods and pathology,
E G Mdurvwa, and
P O Ogunbiyi, and
P G Reddy, and
H S Gakou, and
S O Sodeke, and
A J Carty
January 1993,
Virology,
E G Mdurvwa, and
P O Ogunbiyi, and
P G Reddy, and
H S Gakou, and
S O Sodeke, and
A J Carty
June 2003,
Journal of virology,
E G Mdurvwa, and
P O Ogunbiyi, and
P G Reddy, and
H S Gakou, and
S O Sodeke, and
A J Carty
October 1998,
Clinical chemistry,
E G Mdurvwa, and
P O Ogunbiyi, and
P G Reddy, and
H S Gakou, and
S O Sodeke, and
A J Carty
October 1985,
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B,
E G Mdurvwa, and
P O Ogunbiyi, and
P G Reddy, and
H S Gakou, and
S O Sodeke, and
A J Carty
January 1990,
Current topics in microbiology and immunology,
E G Mdurvwa, and
P O Ogunbiyi, and
P G Reddy, and
H S Gakou, and
S O Sodeke, and
A J Carty
October 1995,
Leukemia,
E G Mdurvwa, and
P O Ogunbiyi, and
P G Reddy, and
H S Gakou, and
S O Sodeke, and
A J Carty
July 1985,
The Veterinary record,
E G Mdurvwa, and
P O Ogunbiyi, and
P G Reddy, and
H S Gakou, and
S O Sodeke, and
A J Carty
June 1984,
American journal of veterinary research,
E G Mdurvwa, and
P O Ogunbiyi, and
P G Reddy, and
H S Gakou, and
S O Sodeke, and
A J Carty
January 2011,
Viruses,
