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Single intrafemoral injection of NMU in the dosage of 80 mg/Kh in mice with ascites leucemia L1210 induced considerable disorders in the tumor cell cycle. The passage of phase S by cells was markedly retarded during the period from 1 hour to 6 days, while after injection of the substance under study a maximum duration of phase G2 increased from 4 to 12 hours. Inhibition of phase S onset was provisional, and already 6 hours following NMU injection all cells entered phase S. In mice mammary tumors the label index fell markedly (by 90%) during the period from 6 hours to 8 days after NMU injection. The intensity of 3H-thymidine incorporation during the whole period of observation was approximately twice reduced.
L A Ostrovskaia, and
O S Frankfurt
February 1996,
Cancer letters,
L A Ostrovskaia, and
O S Frankfurt
January 2006,
Anticancer research,
L A Ostrovskaia, and
O S Frankfurt
January 2004,
Report on carcinogens : carcinogen profiles,
L A Ostrovskaia, and
O S Frankfurt
May 1978,
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man,
L A Ostrovskaia, and
O S Frankfurt
January 2002,
Report on carcinogens : carcinogen profiles,
L A Ostrovskaia, and
O S Frankfurt
January 2005,
Oncology research,
L A Ostrovskaia, and
O S Frankfurt
May 1967,
Die Naturwissenschaften,
L A Ostrovskaia, and
O S Frankfurt
April 1968,
Die Naturwissenschaften,
L A Ostrovskaia, and
O S Frankfurt
November 1996,
Molecular carcinogenesis,
L A Ostrovskaia, and
O S Frankfurt
January 1986,
TSitologiia i genetika,
