Biomaterial Database

Renal response to prostaglandin E1 infusion in polycystic kidney disease versus non-polycystic renal disease. 1995

J Uemasu, and C Munemura, and M Fujihara, and H Kawasaki

Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.

The effect of prostaglandin E1 (PGE1) on renal function was examined in 8 patients with autosomal dominant polycystic kidney disease (ADPKD) and 8 subjects with non-polycystic chronic renal disease (CRD). Intravenous PGE1 infusion (50 micrograms/hr, for 2 hrs) resulted in a significant fall in creatinine clearance in ADPKD, but not in CRD. Although PGE1 had no effect on urinary sodium excretion and osmolar clearance in both groups, it increased significantly free water clearance in CRD, but not in ADPKD. Nephrogenic cyclic AMP during PGE1 administration did not differ significantly from their respective baseline level in two groups. In these groups, although nephrogenic cyclic AMP correlated poorly with urine volume, osmolar clearance, and free water clearance, it demonstrated a significant negative correlation with creatinine clearance. Renal volume in ADPKD cases had no relation with the parameters of renal function examined during PGE1 infusion. These data demonstrate the different responses of polycystic kidneys to PGE1 compared with non-polycystic kidneys.

UI	MeSH Term	Description	Entries
D007262	Infusions, Intravenous	The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.	Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D007674	Kidney Diseases	Pathological processes of the KIDNEY or its component tissues.	Disease, Kidney,Diseases, Kidney,Kidney Disease
D007677	Kidney Function Tests	Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.	Function Test, Kidney,Function Tests, Kidney,Kidney Function Test,Test, Kidney Function,Tests, Kidney Function
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D003404	Creatinine		Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D005260	Female		Females