Biomaterial Database

Repetitive, low-dose tissue plasminogen activator for clearance of experimental vitreous hemorrhage. 1995

P Zhao, and W Wang, and H Song, and Y Zhu

Dept. of Ophthalmology, Eye & ENT Hospital, Shanghai Medical University, China.

OBJECTIVE To investigate the effectiveness of repetitive, low-dose tPA for clearance of experimental vitreous hemorrhage. METHODS The model vitreous hemorrhage was produced by intravitreal injection of 0.05ml of autologous citrated whole blood in 14 rabbits (28 eyes). One week after the creation of vitreous hemorrhage, the eyes were randomly separated into 3 groups. Groups 1 and 2 received two injections of 5 or 25 micrograms of tPA, respectively, with one injection in a 7-day interval. Group 3 received two injections of PS in the same way. RESULTS The clearance of vitreous hemorrhage in tPA-treated groups was significantly faster than that in the control group (P < 0.05, or P < 0.01). However, there was no statistically significant difference between the two tPA-treated groups. Not any retinal toxicity was detected by ERG, light microscopy, and transmission electron microscopy examinations. CONCLUSIONS Repetitive injections of low-dose tPA were effective in the treatment of experimental vitreous hemorrhage. Whether it is effective on the clearance of vitreous hemorrhage in human eyes needs further investigation.

UI	MeSH Term	Description	Entries
D010959	Tissue Plasminogen Activator	A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.	Alteplase,Plasminogen Activator, Tissue-Type,T-Plasminogen Activator,Tissue-Type Plasminogen Activator,Actilyse,Activase,Lysatec rt-PA,TTPA,Tisokinase,Tissue Activator D-44,Lysatec rt PA,Lysatec rtPA,Plasminogen Activator, Tissue,Plasminogen Activator, Tissue Type,T Plasminogen Activator,Tissue Activator D 44,Tissue Type Plasminogen Activator
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D004596	Electroretinography	Recording of electric potentials in the retina after stimulation by light.	Electroretinographies
D005343	Fibrinolytic Agents	Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.	Antithrombic Drug,Antithrombotic Agent,Antithrombotic Agents,Fibrinolytic Agent,Fibrinolytic Drug,Thrombolytic Agent,Thrombolytic Agents,Thrombolytic Drug,Antithrombic Drugs,Fibrinolytic Drugs,Thrombolytic Drugs,Agent, Antithrombotic,Agent, Fibrinolytic,Agent, Thrombolytic,Agents, Antithrombotic,Drug, Antithrombic,Drug, Fibrinolytic,Drug, Thrombolytic,Drugs, Antithrombic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014823	Vitreous Hemorrhage	Hemorrhage into the VITREOUS BODY.	Hemorrhage, Vitreous,Vitreous Hemorrhages