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Biochemical changes in response to a high partial pressure of oxygen were investigated in 12 test subjects. During exposure to compressed oxygen breathing (pO2-0.25 MPa) for a limited period of time changes in the carbohydrate, protein, enzyme, and electrolyte status were seen. These changes were demonstrative sings of physiological and toxic effects of oxygen. Individual metabolic responses were investigated and optimal exposure times were determined. It is recommended to take into consideration biochemical variations when identifying human resistance to oxygen toxicity on an individual basis.
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